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    U2A U2A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35713, updated on 9-Dec-2024

    Summary

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    Official Symbol
    U2Aprovided by FlyBase
    Official Full Name
    U2Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033210
    Locus tag
    Dmel_CG1406
    See related
    AllianceGenome:FB:FBgn0033210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE56869; CG1406; Dmel\CG1406; dU2A; dU2A'; l(2)43Ee; u2a; U2A'; U2A-prime
    Summary
    Predicted to enable U2 snRNA binding activity. Involved in chromatin organization and spermatogenesis. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism; ovary; and testis. Used to study azoospermia. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See U2A in Genome Data Viewer
    Location:
    43E9-43E9; 2-57 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7675362..7676362, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3562867..3563867, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene uncharacterized protein Neighboring gene Leucine-rich repeat Neighboring gene uncharacterized protein Neighboring gene Coenzyme Q9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Linkage and allostery in snRNP protein/RNA complexes. Williams SG, et al. Biochemistry, 2014 Jun 10. PMID 24849693, Free PMC Article
    2. Functioning of the Drosophila Wilms'-tumor-1-associated protein homolog, Fl(2)d, in Sex-lethal-dependent alternative splicing. Penn JK, et al. Genetics, 2008 Feb. PMID 18245840, Free PMC Article
    3. Prp22 and spliceosome components regulate chromatin dynamics in germ-line polyploid cells. Klusza S, et al. PLoS One, 2013. PMID 24244416, Free PMC Article
    4. Kin17 regulates proper cortical localization of Miranda in Drosophila neuroblasts by regulating Flfl expression. Connell M, et al. Cell Rep, 2024 Mar 26. PMID 38386552, Free PMC Article
    5. Molecular principles underlying dual RNA specificity in the Drosophila SNF protein. Weber G, et al. Nat Commun, 2018 Jun 7. PMID 29880797, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables U2 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of small nuclear ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U2A
    Names
    CG1406-PA
    U2A-PA
    lethal(2)43Ee

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7675362..7676362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136471.4 → NP_610315.1  U2A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610315.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V4Q8
      Related
      FBpp0088015
      Conserved Domains (4) summary
      pfam14580
      Location:1 → 175
      LRR_9; Leucine-rich repeat
      sd00031
      Location:46 → 65
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:22 → 43
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:46 → 81
      LRR_4; Leucine Rich repeats (2 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V4Q8.1 Q9V4Q8

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