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    Dgp-1 Dgp-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dgp-1provided by FlyBase
    Official Full Name
    Dgp-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027836
    Locus tag
    Dmel_CG5729
    See related
    AllianceGenome:FB:FBgn0027836
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5729; DGP-1; Dmel\CG5729
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Is expressed in adult head. Orthologous to human GTPBP1 (GTP binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dgp-1 in Genome Data Viewer
    Location:
    55B11-55B11; 2-84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18168413..18172607, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14055918..14060112, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Nausicaa Neighboring gene Nucleoporin 75kD Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 9 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of isoform B of Dgp-1 gene enhances locomotor activity in senescent Drosophila males and under heat stress. Fedotov SA, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2019 Dec. PMID 31686134
    2. Bi-allelic genetic variants in the translational GTPases GTPBP1 and GTPBP2 cause a distinct identical neurodevelopmental syndrome. Salpietro V, et al. Am J Hum Genet, 2024 Jan 4. PMID 38118446, Free PMC Article
    3. no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila. Merkle JA, et al. Development, 2009 Feb. PMID 19141674, Free PMC Article
    4. The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development. Huang HW, et al. J Cell Sci, 2017 Sep 15. PMID 28775151, Free PMC Article
    5. The effect of neurospecific knockdown of candidate genes for locomotor behavior and sound production in Drosophila melanogaster. Fedotov SA, et al. Fly (Austin), 2014. PMID 25494872, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of isoform B of Dgp-1 gene enhances locomotor activity in senescent Drosophila males and under heat stress.
      Title: Overexpression of isoform B of Dgp-1 gene enhances locomotor activity in senescent Drosophila males and under heat stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Dgp-1
    Names
    CG5729-PA
    CG5729-PB
    Dgp-1-PA
    Dgp-1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18168413..18172607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137458.3 → NP_611302.1  Dgp-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611302.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEL6, Q0E931, Q8MS03
      Related
      FBpp0085953
      Conserved Domains (4) summary
      cd04165
      Location:145 → 367
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      COG5258
      Location:38 → 555
      GTPBP1; GTPase [General function prediction only]
      cd03694
      Location:376 → 462
      GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
      cd03708
      Location:468 → 553
      GTPBP_III; Domain III of the GP-1 family of GTPases

    2. NM_166274.2 → NP_725760.1  Dgp-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725760.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEL6, Q0E931, Q8MS03
      Related
      FBpp0085952
      Conserved Domains (4) summary
      cd04165
      Location:145 → 367
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      COG5258
      Location:38 → 555
      GTPBP1; GTPase [General function prediction only]
      cd03694
      Location:376 → 462
      GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
      cd03708
      Location:468 → 553
      GTPBP_III; Domain III of the GP-1 family of GTPases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E931 Q0E931
    Q8MS03 Q8MS03
    Q9U9K4 Q9U9K4

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