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    Zdhhc18 zinc finger DHHC-type palmitoyltransferase 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362613, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zdhhc18provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 18provided by RGD
    Primary source
    RGD:1309334
    See related
    EnsemblRapid:ENSRNOG00000058156 AllianceGenome:RGD:1309334
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DHHC-18
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation; protein targeting to membrane; and regulation of innate immune response. Predicted to act upstream of or within protein localization. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC18 (zinc finger DHHC-type palmitoyltransferase 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 118.7), Lung (RPKM 69.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc18 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151105303..151143843, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145821534..145859989, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151829795..151856256, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL29-like Neighboring gene G patch domain containing 3 Neighboring gene GPN-loop GTPase 2 Neighboring gene stratifin Neighboring gene U6 spliceosomal RNA Neighboring gene solute carrier family 25 member 33, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
    2. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Ohno Y, et al. Mol Biol Cell, 2012 Dec. PMID 23034182, Free PMC Article
    3. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cGAS/STING signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cGAS/STING signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC18
    Names
    membrane-associated DHHC18 zinc finger protein
    zinc finger DHHC domain-containing protein 18
    zinc finger, DHHC domain containing 18
    zinc finger, DHHC-type containing 18
    NP_001034428.2
    XP_038966311.1
    XP_038966312.1
    XP_038966313.1
    XP_038966315.1
    XP_038966317.1
    XP_038966318.1
    XP_038966319.1
    XP_063144129.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039339.3 → NP_001034428.2  palmitoyltransferase ZDHHC18

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZYY4
      Related
      ENSRNOP00000084298.1, ENSRNOT00000111487.2
      Conserved Domains (1) summary
      cl19890
      Location:106 → 320
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      151105303..151143843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110387.2 → XP_038966315.1  palmitoyltransferase ZDHHC18 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZYY4
      Related
      ENSRNOP00000101810.1, ENSRNOT00000140237.1
      Conserved Domains (1) summary
      pfam01529
      Location:189 → 312
      DHHC; DHHC palmitoyltransferase

    2. XM_039110390.2 → XP_038966318.1  palmitoyltransferase ZDHHC18 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZYY4
      Conserved Domains (1) summary
      pfam01529
      Location:189 → 312
      DHHC; DHHC palmitoyltransferase

    3. XM_039110385.2 → XP_038966313.1  palmitoyltransferase ZDHHC18 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZYY4
      Related
      ENSRNOP00000083003.2, ENSRNOT00000103827.2
      Conserved Domains (1) summary
      pfam01529
      Location:189 → 312
      DHHC; DHHC palmitoyltransferase

    4. XM_039110383.2 → XP_038966311.1  palmitoyltransferase ZDHHC18 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:189 → 312
      DHHC; DHHC palmitoyltransferase

    5. XM_039110384.2 → XP_038966312.1  palmitoyltransferase ZDHHC18 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYY4
      Related
      ENSRNOP00000073628.3, ENSRNOT00000081470.3
      Conserved Domains (1) summary
      pfam01529
      Location:189 → 312
      DHHC; DHHC palmitoyltransferase

    6. XM_039110389.2 → XP_038966317.1  palmitoyltransferase ZDHHC18 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K605, A0A8I5ZYY4
      Conserved Domains (1) summary
      pfam01529
      Location:189 → 312
      DHHC; DHHC palmitoyltransferase

    7. XM_063288059.1 → XP_063144129.1  palmitoyltransferase ZDHHC18 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K605, A0A8I5ZYY4
      Related
      ENSRNOP00000109196.1, ENSRNOT00000157390.1

    8. XM_039110391.2 → XP_038966319.1  palmitoyltransferase ZDHHC18 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZUZ6, A0A8I5ZYY4
      Conserved Domains (1) summary
      pfam01529
      Location:189 → 312
      DHHC; DHHC palmitoyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2TGJ1.1 GenPept UniProtKB/Swiss-Prot:Q2TGJ1

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