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    Klhl25 kelch-like 25 [ Mus musculus (house mouse) ]

    Gene ID: 207952, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl25provided by MGI
    Official Full Name
    kelch-like 25provided by MGI
    Primary source
    MGI:MGI:2668031
    See related
    Ensembl:ENSMUSG00000055652 AllianceGenome:MGI:2668031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Enc-1; 2810402K13Rik
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of fatty acid oxidation; and ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. Is expressed in central nervous system; nervous system; peripheral nervous system; and retina. Orthologous to human KLHL25 (kelch like family member 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.7), ovary adult (RPKM 15.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl25 in Genome Data Viewer
    Location:
    7 D1; 7 43.81 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (75498086..75523881)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (75848338..75874133)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19225 Neighboring gene STARR-seq mESC enhancer starr_19226 Neighboring gene STARR-positive B cell enhancer ABC_E2824 Neighboring gene CRISPRi-validated cis-regulatory element for Akap13 Neighboring gene STARR-positive B cell enhancer ABC_E6559 Neighboring gene STARR-positive B cell enhancer ABC_E2825 Neighboring gene expressed sequence AU020206 Neighboring gene STARR-positive B cell enhancer ABC_E6560 Neighboring gene STARR-seq mESC enhancer starr_19228 Neighboring gene STARR-seq mESC enhancer starr_19229 Neighboring gene STARR-positive B cell enhancer ABC_E447 Neighboring gene predicted gene, 51489 Neighboring gene STARR-seq mESC enhancer starr_19230 Neighboring gene STARR-seq mESC enhancer starr_19231 Neighboring gene VISTA enhancer mm485 Neighboring gene STARR-seq mESC enhancer starr_19234 Neighboring gene predicted gene, 51413 Neighboring gene STARR-seq mESC enhancer starr_19235 Neighboring gene predicted gene, 51518

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation. Tian M, et al. Elife, 2021 Sep 7. PMID 34491895, Free PMC Article
    2. Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice. Ikegami K, et al. Sci Rep, 2019 Sep 20. PMID 31541165, Free PMC Article
    3. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Hrabé de Angelis MH, et al. Nat Genet, 2000 Aug. PMID 10932192
    4. A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex. Najas S, et al. Development, 2020 Jul 13. PMID 32541003
    5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36331

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fatty acid oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 25
    Names
    ENC-2
    ectoderm-neural cortex protein 2
    ectoderm-neural cortex-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122780.1 → NP_001116252.1  kelch-like protein 25

      See identical proteins and their annotated locations for NP_001116252.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same the protein.
      Source sequence(s)
      AK143086, BY241272
      Consensus CDS
      CCDS21369.1
      UniProtKB/Swiss-Prot
      Q8R2P1
      Related
      ENSMUSP00000133175.3, ENSMUST00000171155.4
      Conserved Domains (3) summary
      PHA03098
      Location:39 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 374
      Kelch; KELCH repeat [structural motif]
      cd18254
      Location:24 → 151
      BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)

    2. NM_029652.1 → NP_083928.1  kelch-like protein 25

      See identical proteins and their annotated locations for NP_083928.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same the protein.
      Source sequence(s)
      AK143086, BY042513, BY241272
      Consensus CDS
      CCDS21369.1
      UniProtKB/Swiss-Prot
      Q8R2P1
      Related
      ENSMUSP00000089707.6, ENSMUST00000092073.11
      Conserved Domains (3) summary
      PHA03098
      Location:39 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 374
      Kelch; KELCH repeat [structural motif]
      cd18254
      Location:24 → 151
      BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)

    3. NM_182782.2 → NP_877583.1  kelch-like protein 25

      See identical proteins and their annotated locations for NP_877583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1. Variants 1-3 encode the same the protein.
      Source sequence(s)
      AK143086, BP767188, BY042513, BY241272
      Consensus CDS
      CCDS21369.1
      UniProtKB/Swiss-Prot
      Q8R2P1
      Related
      ENSMUSP00000146102.2, ENSMUST00000206019.2
      Conserved Domains (3) summary
      PHA03098
      Location:39 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 374
      Kelch; KELCH repeat [structural motif]
      cd18254
      Location:24 → 151
      BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      75498086..75523881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250832.3 → XP_011249134.1  kelch-like protein 25 isoform X1

      See identical proteins and their annotated locations for XP_011249134.1

      UniProtKB/Swiss-Prot
      Q8R2P1
      Conserved Domains (3) summary
      PHA03098
      Location:39 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 374
      Kelch; KELCH repeat [structural motif]
      cd18254
      Location:24 → 151
      BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2P1.1 GenPept UniProtKB/Swiss-Prot:Q8R2P1

    Gene LinkOut

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