U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Rbm28 RNA binding motif protein 28 [ Mus musculus (house mouse) ]

    Gene ID: 68272, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbm28provided by MGI
    Official Full Name
    RNA binding motif protein 28provided by MGI
    Primary source
    MGI:MGI:2655711
    See related
    Ensembl:ENSMUSG00000029701 AllianceGenome:MGI:2655711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810480G15Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be part of spliceosomal complex. Predicted to be active in nucleolus. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene implicated in alopecia, neurologic defects, and endocrinopathy syndrome. Orthologous to human RBM28 (RNA binding motif protein 28). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 20.2), CNS E18 (RPKM 15.5) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rbm28 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.33 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29123572..29164975, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29123573..29164724, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Lep proximal promoter region Neighboring gene leptin Neighboring gene STARR-seq mESC enhancer starr_15433 Neighboring gene predicted gene, 25589 Neighboring gene STARR-positive B cell enhancer ABC_E3646 Neighboring gene proline-rich transmembrane protein 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29155327-29155436 Neighboring gene STARR-positive B cell enhancer ABC_E8096 Neighboring gene inosine monophosphate dehydrogenase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC12075, MGC38664

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133925.2NP_598686.2  RNA-binding protein 28

      See identical proteins and their annotated locations for NP_598686.2

      Status: VALIDATED

      Source sequence(s)
      AA212598, AK087628, AK161670, AK167050, AW123167
      Consensus CDS
      CCDS51733.1
      UniProtKB/Swiss-Prot
      E9QKF8, Q3U0K5, Q8BG25, Q8CGC6, Q8VEJ8, Q9CS22, Q9CSE6
      Related
      ENSMUSP00000007993.10, ENSMUST00000007993.16
      Conserved Domains (5) summary
      PTZ00108
      Location:563740
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd12413
      Location:581
      RRM1_RBM28_like; RNA recognition motif 1 (RRM1) found in RNA-binding protein 28 (RBM28) and similar proteins
      cd12414
      Location:115190
      RRM2_RBM28_like; RNA recognition motif 2 (RRM2) found in RNA-binding protein 28 (RBM28) and similar proteins
      cd12415
      Location:325407
      RRM3_RBM28_like; RNA recognition motif 3 (RRM3) found in RNA-binding protein 28 (RBM28) and similar proteins
      cd12416
      Location:477571
      RRM4_RBM28_like; RNA recognition motif 4 (RRM4) found in RNA-binding protein 28 (RBM28) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29123572..29164975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152280.1XP_036008173.1  RNA-binding protein 28 isoform X1

      Conserved Domains (3) summary
      TIGR01628
      Location:82330
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12416
      Location:104198
      RRM4_RBM28_like; RNA recognition motif 4 (RRM4) found in RNA-binding protein 28 (RBM28) and similar proteins
      cl17169
      Location:234
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. XM_030255573.2XP_030111433.1  RNA-binding protein 28 isoform X1

      Conserved Domains (3) summary
      TIGR01628
      Location:82330
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12416
      Location:104198
      RRM4_RBM28_like; RNA recognition motif 4 (RRM4) found in RNA-binding protein 28 (RBM28) and similar proteins
      cl17169
      Location:234
      RRM_SF; RNA recognition motif (RRM) superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026650.1: Suppressed sequence

      Description
      NM_026650.1: This RefSeq was temporarily suppressed because the CDS was partial, and there is not sufficient data to support this transcript.