ttm2 tiny tim 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ttm2provided by FlyBase
Official Full Name: tiny tim 2provided by FlyBase
Primary source: FLYBASE:FBgn0035124
Locus tag: Dmel_CG12313
See related: AllianceGenome:FB:FBgn0035124
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 20130405; CG12313; Dmel\CG12313
Summary: Predicted to enable protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; and ribonucleoprotein complex binding activity. Predicted to be involved in mitochondrial membrane organization; protein dephosphorylation; and protein import into mitochondrial matrix. Predicted to be located in mitochondrial inner membrane and nuclear speck. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Is expressed in adult head. Used to study cancer. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 9. Orthologous to human TIMM50 (translocase of inner mitochondrial membrane 50). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (275155..276667)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (275155..276667)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Context-Dependent Tumorigenic Effect of Testis-Specific Mitochondrial Protein Tiny Tim 2 in Drosophila Somatic Epithelia.
Title: Context-Dependent Tumorigenic Effect of Testis-Specific Mitochondrial Protein Tiny Tim 2 in Drosophila Somatic Epithelia.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribonucleoprotein complex binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitochondrial membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM23 mitochondrial import inner membrane translocase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info