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    HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 [ Gallus gallus (chicken) ]

    Gene ID: 418682, updated on 3-Dec-2024

    Summary

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    Official Symbol
    HERC2provided by CGNC
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase 2provided by CGNC
    Primary source
    CGNC:12553
    See related
    Ensembl:ENSGALG00010002886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See HERC2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    94
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (130613024..130718286)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (130568938..130674056)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107051964 Neighboring gene non imprinted in Prader-Willi/Angelman syndrome 1 Neighboring gene uncharacterized LOC100858753 Neighboring gene OCA2 melanosomal transmembrane protein Neighboring gene uncharacterized LOC121107738

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells. Oestergaard VH, et al. DNA Repair (Amst), 2012 Nov 1. PMID 23010445
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HERC2 is not required for survival or for ubiquitin foci formation after DNA damage in DT40.
      Title: RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HERC2
    Names
    hect domain and RLD 2
    NP_001239305.2
    XP_015133198.2
    XP_015133199.2
    XP_040555018.1
    XP_040555024.1
    XP_046764006.1
    XP_046764007.1
    XP_046764008.1
    XP_046764009.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252376.3 → NP_001239305.2  E3 ubiquitin-protein ligase HERC2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000025
      UniProtKB/TrEMBL
      A0A8V0XBP7
      Conserved Domains (5) summary
      cd08664
      Location:2769 → 2914
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:2956 → 3326
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4426 → 4797
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2710 → 2754
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2462 → 2509
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      130613024..130718286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015277713.4 → XP_015133199.2  E3 ubiquitin-protein ligase HERC2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XBP7
      Related
      ENSGALP00010004096.1, ENSGALT00010006692.1
      Conserved Domains (5) summary
      cd08664
      Location:2769 → 2914
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:2956 → 3326
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4390 → 4761
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2710 → 2754
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2462 → 2509
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

    2. XM_015277712.4 → XP_015133198.2  E3 ubiquitin-protein ligase HERC2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XBP7, A0A8V0XEM6
      Related
      ENSGALP00010004094.1, ENSGALT00010006688.1
      Conserved Domains (5) summary
      cd08664
      Location:2764 → 2909
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:2951 → 3321
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4421 → 4792
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2705 → 2749
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2457 → 2504
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

    3. XM_040699084.2 → XP_040555018.1  E3 ubiquitin-protein ligase HERC2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XBP7
      Conserved Domains (5) summary
      cd08664
      Location:2769 → 2914
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:2956 → 3326
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4426 → 4797
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2710 → 2754
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2462 → 2509
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

    4. XM_040699090.2 → XP_040555024.1  E3 ubiquitin-protein ligase HERC2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XBP7, A0A8V0XEM6
      Conserved Domains (5) summary
      cd08664
      Location:2764 → 2909
      APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
      COG5184
      Location:2951 → 3321
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4421 → 4792
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd02344
      Location:2705 → 2749
      ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
      cd14402
      Location:2457 → 2504
      UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      130568938..130674056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046908053.1 → XP_046764009.1  E3 ubiquitin-protein ligase HERC2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XBP7

    2. XM_046908051.1 → XP_046764007.1  E3 ubiquitin-protein ligase HERC2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XBP7

    3. XM_046908050.1 → XP_046764006.1  E3 ubiquitin-protein ligase HERC2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XBP7

    4. XM_046908052.1 → XP_046764008.1  E3 ubiquitin-protein ligase HERC2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XBP7
    Nucleotide Protein Strain
    Heading Accession and Version

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