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    EPS8 epidermal growth factor receptor pathway substrate 8 [ Gallus gallus (chicken) ]

    Gene ID: 418174, updated on 3-Dec-2024

    Summary

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    Symbol
    EPS8provided by CGNC
    Full Name
    epidermal growth factor receptor pathway substrate 8provided by CGNC
    Primary source
    CGNC:9898
    See related
    Ensembl:ENSGALG00010012768
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See EPS8 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (62993338..63124573, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (63313467..63444278, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene RAS like estrogen regulated growth inhibitor Neighboring gene protein tyrosine phosphatase, receptor type O Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC121108252 Neighboring gene uncharacterized LOC107054199 Neighboring gene serine/threonine kinase receptor associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    epidermal growth factor receptor kinase substrate 8

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      62993338..63124573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040655696.2 → XP_040511630.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YFU5
      Conserved Domains (3) summary
      cd09540
      Location:693 → 757
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:503 → 556
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    2. XM_416405.8 → XP_416405.4  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Related
      ENSGALP00010017771.1, ENSGALT00010030652.1
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    3. XM_040655645.2 → XP_040511579.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Related
      ENSGALP00010017786.1, ENSGALT00010030673.1
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    4. XM_004937964.5 → XP_004938021.2  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YFU5
      Conserved Domains (3) summary
      cd09540
      Location:693 → 757
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:503 → 556
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    5. XM_004937962.5 → XP_004938019.2  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Related
      ENSGALP00010017765.1, ENSGALT00010030630.1
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    6. XM_040655688.2 → XP_040511622.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YFU5
      Related
      ENSGALP00010017749.1, ENSGALT00010030593.1
      Conserved Domains (3) summary
      cd09540
      Location:693 → 757
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:503 → 556
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    7. XM_004937963.5 → XP_004938020.2  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Related
      ENSGALP00010017754.1, ENSGALT00010030604.1
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    8. XM_046904964.1 → XP_046760920.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6

    9. XM_040655647.2 → XP_040511581.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    10. XM_046904968.1 → XP_046760924.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6

    11. XM_046904971.1 → XP_046760927.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6

    12. XM_046904976.1 → XP_046760932.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6

    13. XM_015292046.4 → XP_015147532.2  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    14. XM_040655679.2 → XP_040511613.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    15. XM_040655671.2 → XP_040511605.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      63313467..63444278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040658941.2 → XP_040514875.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YFU5
      Conserved Domains (3) summary
      cd09540
      Location:693 → 757
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:503 → 556
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    2. XM_040658938.2 → XP_040514872.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    3. XM_040658931.2 → XP_040514865.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    4. XM_040658939.2 → XP_040514873.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YFU5
      Conserved Domains (3) summary
      cd09540
      Location:693 → 757
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:503 → 556
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    5. XM_040658929.2 → XP_040514863.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    6. XM_040658940.2 → XP_040514874.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YFU5
      Conserved Domains (3) summary
      cd09540
      Location:693 → 757
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:503 → 556
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    7. XM_040658930.2 → XP_040514864.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    8. XM_046909816.1 → XP_046765772.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6

    9. XM_040658933.2 → XP_040514867.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    10. XM_046909817.1 → XP_046765773.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6

    11. XM_046909818.1 → XP_046765774.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6

    12. XM_046909819.1 → XP_046765775.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6

    13. XM_040658935.2 → XP_040514869.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    14. XM_040658937.2 → XP_040514871.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    15. XM_040658936.2 → XP_040514870.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YAK0, A0A8V0YIZ6
      Conserved Domains (3) summary
      cd09540
      Location:726 → 790
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:536 → 589
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:61 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    Nucleotide Protein Strain
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