PLXNA4 plexin A4 [Gallus gallus (chicken)] - Gene

Summary

Symbol: PLXNA4provided by CGNC
Full Name: plexin A4provided by CGNC
Primary source: CGNC:4879
See related: Ensembl:ENSGALG00010005333
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: PLXNA4B
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (2830517..3284954)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (2833755..3288174)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that by interacting with PlexA4, TrkA plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 localization and patterning.
Title: TrkA mediates retrograde semaphorin 3A signaling through plexin A4 to regulate dendritic branching.

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General gene information

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Markers

MCW0168 (e-PCR), detects polymorphism
- UniSTS:280170

MARC_9713-9714:996688545:1 (e-PCR)
- UniSTS:269978

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of axonogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info	PubMed
involved_in semaphorin-plexin signaling pathway involved in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of semaphorin receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: plexin-A4

Names: plexin A4, B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

2830517..3284954

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040663912.2 → XP_040519846.1 plexin-A4 isoform X1

UniProtKB/TrEMBL

F1NZB0

Related

ENSGALP00010007217.1, ENSGALT00010012653.1

Conserved Domains (8) summary

cd11274
Location:36 → 508

Sema_plexin_A4; The Sema domain, a protein interacting module, of Plexin A4

cd12790
Location:1309 → 1886

RasGAP_plexin_A; Ras-GTPase Activating Domain of type A plexins

smart00423
Location:507 → 545

PSI; domain found in Plexins, Semaphorins and Integrins

cd00603
Location:1140 → 1220

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01179
Location:952 → 1036

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:855 → 950

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1038 → 1138

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cl28922
Location:1507 → 1598

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_015291826.4 → XP_015147312.2 plexin-A4 isoform X2

Conserved Domains (4) summary

cd11274
Location:36 → 508

Sema_plexin_A4; The Sema domain, a protein interacting module, of Plexin A4

smart00423
Location:507 → 545

PSI; domain found in Plexins, Semaphorins and Integrins

pfam01437
Location:652 → 690

PSI; Plexin repeat

pfam17960
Location:561 → 651

TIG_plexin; TIG domain
XM_015291976.4 → XP_015147462.1 plexin-A4 isoform X3

Conserved Domains (1) summary

cl15693
Location:36 → 455

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_040663921.2 → XP_040519855.1 plexin-A4 isoform X1

UniProtKB/TrEMBL

F1NZB0

Conserved Domains (8) summary

cd11274
Location:36 → 508

Sema_plexin_A4; The Sema domain, a protein interacting module, of Plexin A4

cd12790
Location:1309 → 1886

RasGAP_plexin_A; Ras-GTPase Activating Domain of type A plexins

smart00423
Location:507 → 545

PSI; domain found in Plexins, Semaphorins and Integrins

cd00603
Location:1140 → 1220

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01179
Location:952 → 1036

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:855 → 950

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1038 → 1138

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cl28922
Location:1507 → 1598

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

2833755..3288174

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040659988.2 → XP_040515922.1 plexin-A4 isoform X1

UniProtKB/TrEMBL

F1NZB0

Conserved Domains (8) summary

cd11274
Location:36 → 508

Sema_plexin_A4; The Sema domain, a protein interacting module, of Plexin A4

cd12790
Location:1309 → 1886

RasGAP_plexin_A; Ras-GTPase Activating Domain of type A plexins

smart00423
Location:507 → 545

PSI; domain found in Plexins, Semaphorins and Integrins

cd00603
Location:1140 → 1220

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01179
Location:952 → 1036

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:855 → 950

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1038 → 1138

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cl28922
Location:1507 → 1598

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_040659990.2 → XP_040515924.1 plexin-A4 isoform X2

Conserved Domains (4) summary

cd11274
Location:36 → 508

Sema_plexin_A4; The Sema domain, a protein interacting module, of Plexin A4

smart00423
Location:507 → 545

PSI; domain found in Plexins, Semaphorins and Integrins

pfam01437
Location:652 → 690

PSI; Plexin repeat

pfam17960
Location:561 → 651

TIG_plexin; TIG domain
XM_040659991.2 → XP_040515925.1 plexin-A4 isoform X3

Conserved Domains (1) summary

cl15693
Location:36 → 455

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_040659989.2 → XP_040515923.1 plexin-A4 isoform X1

UniProtKB/TrEMBL

F1NZB0

Conserved Domains (8) summary

cd11274
Location:36 → 508

Sema_plexin_A4; The Sema domain, a protein interacting module, of Plexin A4

cd12790
Location:1309 → 1886

RasGAP_plexin_A; Ras-GTPase Activating Domain of type A plexins

smart00423
Location:507 → 545

PSI; domain found in Plexins, Semaphorins and Integrins

cd00603
Location:1140 → 1220

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01179
Location:952 → 1036

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:855 → 950

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1038 → 1138

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cl28922
Location:1507 → 1598

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold