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    ITSN1 intersectin 1 [ Gallus gallus (chicken) ]

    Gene ID: 418506, updated on 3-Dec-2024

    Summary

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    Symbol
    ITSN1provided by CGNC
    Full Name
    intersectin 1provided by CGNC
    Primary source
    CGNC:11953
    See related
    Ensembl:ENSGALG00010012195
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ITSN1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (105555555..105674648)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (105644488..105763718)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene downstream neighbor of SON Neighboring gene crystallin zeta like 1 Neighboring gene uncharacterized LOC107055362 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit Neighboring gene solute carrier family 5 member 3 Neighboring gene mitochondrial ribosomal protein S6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    intersectin-1
    Names
    intersectin 1 (SH3 domain protein)

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      105555555..105674648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040666360.2 → XP_040522294.1  intersectin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YF29
      Related
      ENSGALP00010017517.1, ENSGALT00010030163.1
      Conserved Domains (11) summary
      cd08375
      Location:1575 → 1709
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:741 → 800
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:912 → 963
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:1001 → 1052
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11995
      Location:1151 → 1204
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG1196
      Location:362 → 705
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00160
      Location:1231 → 1414
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1441 → 1572
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      cl17036
      Location:1069 → 1131
      SH3; Src Homology 3 domain superfamily

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      105644488..105763718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040661985.2 → XP_040517919.1  intersectin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (11) summary
      cd08375
      Location:1608 → 1742
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:772 → 831
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:943 → 994
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:1032 → 1083
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1100 → 1164
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1184 → 1237
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG0419
      Location:342 → 736
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00160
      Location:1264 → 1447
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1474 → 1605
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain

    2. XM_040661987.2 → XP_040517921.1  intersectin-1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (11) summary
      cd08375
      Location:1603 → 1737
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:772 → 826
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:938 → 989
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:1027 → 1078
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1095 → 1159
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1179 → 1232
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG0419
      Location:342 → 736
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00160
      Location:1259 → 1442
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1469 → 1600
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain

    3. XM_040661988.2 → XP_040517922.1  intersectin-1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (11) summary
      cd08375
      Location:1586 → 1720
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:750 → 809
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:921 → 972
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:1010 → 1061
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1078 → 1142
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1162 → 1215
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG0419
      Location:342 → 738
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00160
      Location:1242 → 1425
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1452 → 1583
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain

    4. XM_040661990.2 → XP_040517924.1  intersectin-1 isoform X7

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (11) summary
      cd08375
      Location:1581 → 1715
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:750 → 804
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:916 → 967
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:1005 → 1056
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1073 → 1137
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1157 → 1210
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG0419
      Location:342 → 738
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00160
      Location:1237 → 1420
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1447 → 1578
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain

    5. XM_040661989.2 → XP_040517923.1  intersectin-1 isoform X6

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (11) summary
      cd08375
      Location:1581 → 1715
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:745 → 804
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:916 → 967
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:1005 → 1056
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1073 → 1137
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1157 → 1210
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG1196
      Location:360 → 698
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00160
      Location:1237 → 1420
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1447 → 1578
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain

    6. XM_040661993.2 → XP_040517927.1  intersectin-1 isoform X10

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (11) summary
      cd08375
      Location:1576 → 1710
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:745 → 799
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:911 → 962
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:1000 → 1051
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1068 → 1132
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1152 → 1205
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG1196
      Location:360 → 698
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00160
      Location:1232 → 1415
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1442 → 1573
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain

    7. XM_040661995.2 → XP_040517929.1  intersectin-1 isoform X12

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (11) summary
      cd08375
      Location:1559 → 1693
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:723 → 782
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:894 → 945
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:983 → 1034
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1051 → 1115
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1135 → 1188
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG1196
      Location:360 → 698
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00160
      Location:1215 → 1398
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1425 → 1556
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain

    8. XM_040661997.2 → XP_040517931.1  intersectin-1 isoform X14

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (11) summary
      cd08375
      Location:1554 → 1688
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:723 → 777
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:889 → 940
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:978 → 1029
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1046 → 1110
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1130 → 1183
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG1196
      Location:360 → 698
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00160
      Location:1210 → 1393
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1420 → 1551
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain

    9. XM_040661986.2 → XP_040517920.1  intersectin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (12) summary
      cd08375
      Location:1604 → 1738
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:768 → 827
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:939 → 990
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:1028 → 1079
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1096 → 1160
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1180 → 1233
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG0419
      Location:342 → 732
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00160
      Location:1260 → 1443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:827 → 939
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1462 → 1604
      PH_13; Pleckstrin homology domain

    10. XM_040661992.2 → XP_040517926.1  intersectin-1 isoform X9

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (12) summary
      cd08375
      Location:1577 → 1711
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:746 → 800
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:912 → 963
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:1001 → 1052
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1069 → 1133
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1153 → 1206
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG0419
      Location:342 → 728
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00160
      Location:1233 → 1416
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:800 → 912
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1435 → 1577
      PH_13; Pleckstrin homology domain

    11. XM_040661991.2 → XP_040517925.1  intersectin-1 isoform X8

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (12) summary
      cd08375
      Location:1577 → 1711
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:741 → 800
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:912 → 963
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:1001 → 1052
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1069 → 1133
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1153 → 1206
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG1196
      Location:362 → 705
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00160
      Location:1233 → 1416
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:800 → 912
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1435 → 1577
      PH_13; Pleckstrin homology domain

    12. XM_040661994.2 → XP_040517928.1  intersectin-1 isoform X11

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (12) summary
      cd08375
      Location:1572 → 1706
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:741 → 795
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:907 → 958
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:996 → 1047
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1064 → 1128
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1148 → 1201
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG1196
      Location:362 → 705
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00160
      Location:1228 → 1411
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:795 → 907
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1430 → 1572
      PH_13; Pleckstrin homology domain

    13. XM_040661996.2 → XP_040517930.1  intersectin-1 isoform X13

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (11) summary
      cd08375
      Location:1555 → 1689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:719 → 778
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:890 → 941
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:979 → 1030
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1047 → 1111
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1131 → 1184
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG1196
      Location:360 → 694
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00160
      Location:1211 → 1394
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1421 → 1552
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain

    14. XM_040661998.2 → XP_040517932.1  intersectin-1 isoform X15

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (11) summary
      cd08375
      Location:1550 → 1684
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:719 → 773
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:885 → 936
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:974 → 1025
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1042 → 1106
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1126 → 1179
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG1196
      Location:360 → 694
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00160
      Location:1206 → 1389
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1416 → 1547
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain

    15. XM_040661999.2 → XP_040517933.1  intersectin-1 isoform X16

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (10) summary
      cd08375
      Location:1548 → 1682
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:153 → 248
      EH; Eps15 homology domain
      cd11987
      Location:712 → 771
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:883 → 934
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:972 → 1023
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1040 → 1104
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1124 → 1177
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG0419
      Location:282 → 676
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00160
      Location:1204 → 1387
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1414 → 1545
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain

    16. XM_040662000.2 → XP_040517934.1  intersectin-1 isoform X17

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (11) summary
      cd08375
      Location:1544 → 1678
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:153 → 248
      EH; Eps15 homology domain
      cd11987
      Location:708 → 767
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:879 → 930
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:968 → 1019
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1036 → 1100
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1120 → 1173
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00160
      Location:1200 → 1383
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:287 → 674
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16617
      Location:767 → 879
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1402 → 1544
      PH_13; Pleckstrin homology domain

    17. XM_040662001.2 → XP_040517935.1  intersectin-1 isoform X19

      UniProtKB/TrEMBL
      A0A8V0YF29
      Conserved Domains (11) summary
      cd08375
      Location:1517 → 1651
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:153 → 248
      EH; Eps15 homology domain
      cd11987
      Location:681 → 740
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:852 → 903
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:941 → 992
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1009 → 1073
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1093 → 1146
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      COG1196
      Location:302 → 645
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00160
      Location:1173 → 1356
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:740 → 852
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1375 → 1517
      PH_13; Pleckstrin homology domain

    18. XM_046909968.1 → XP_046765924.1  intersectin-1 isoform X20

      UniProtKB/TrEMBL
      A0A8V0YF29

    19. XM_046909969.1 → XP_046765925.1  intersectin-1 isoform X21

      UniProtKB/TrEMBL
      A0A8V0YF29

    20. XM_046909967.1 → XP_046765923.1  intersectin-1 isoform X18

      UniProtKB/TrEMBL
      A0A8V0YF29

    21. XM_040662002.2 → XP_040517936.1  intersectin-1 isoform X22

      UniProtKB/TrEMBL
      A0A8V0Y9F5
      Conserved Domains (7) summary
      smart00027
      Location:213 → 308
      EH; Eps15 homology domain
      cd11987
      Location:741 → 795
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11991
      Location:996 → 1047
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11995
      Location:1148 → 1201
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      PLN02983
      Location:131 → 201
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      COG1196
      Location:362 → 705
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl17036
      Location:1064 → 1128
      SH3; Src Homology 3 domain superfamily

    22. XM_046909965.1 → XP_046765921.1  intersectin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YF29
    Nucleotide Protein Strain
    Heading Accession and Version

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