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    FES FES proto-oncogene, tyrosine kinase [ Gallus gallus (chicken) ]

    Gene ID: 429374, updated on 3-Dec-2024

    Summary

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    Symbol
    FESprovided by CGNC
    Full Name
    FES proto-oncogene, tyrosine kinaseprovided by CGNC
    Primary source
    CGNC:53636
    See related
    Ensembl:ENSGALG00010000049
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    c-fps
    Orthologs
    human mouse all
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    Genomic context

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    See FES in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (20122116..20127915, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (19986430..19992229, complement)

    Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101751992 Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene microRNA mir-12218 Neighboring gene microfibrillar associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence and topography of chicken c-fps. Genesis of a retroviral oncogene encoding a tyrosine-specific protein kinase. Huang CC, et al. J Mol Biol, 1985 Jan 20. PMID 3879969
    2. Defining the borders of the chicken proto-fps gene, a precursor of Fujinami sarcoma virus. Pfaff SL, et al. Virology, 1985 Oct 30. PMID 2996222
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase Fes/Fps
    Names
    c-fps proto oncogene
    feline sarcoma oncogene
    XP_003641916.5
    XP_015147644.1
    XP_015147646.1
    XP_015147647.1
    XP_040536333.1
    XP_040536334.2
    XP_040536335.1
    XP_040536336.1
    XP_046755166.1
    XP_046781127.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      20122116..20127915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003641868.5 → XP_003641916.5  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      Q90778
      Related
      ENSGALP00010000048.1, ENSGALT00010000072.1

    2. XM_015292160.4 → XP_015147646.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      Q90778
      Conserved Domains (4) summary
      cd07685
      Location:7 → 243
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:455 → 539
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:566 → 817
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:565 → 816
      Pkinase_Tyr; Protein tyrosine kinase

    3. XM_015292158.4 → XP_015147644.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/TrEMBL
      A0A8V0X6E7
      Conserved Domains (4) summary
      cd07685
      Location:61 → 297
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:509 → 593
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:620 → 871
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:619 → 870
      Pkinase_Tyr; Protein tyrosine kinase

    4. XM_015292161.4 → XP_015147647.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      Q90778
      Conserved Domains (4) summary
      cd07685
      Location:7 → 243
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:455 → 539
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:566 → 817
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:565 → 816
      Pkinase_Tyr; Protein tyrosine kinase

    5. XM_046899210.1 → XP_046755166.1  tyrosine-protein kinase Fes/Fps isoform X3

      UniProtKB/TrEMBL
      Q90778

    RNA

    1. XR_003076974.3 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      19986430..19992229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040680400.2 → XP_040536334.2  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      Q90778

    2. XM_040680401.2 → XP_040536335.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      Q90778
      Conserved Domains (3) summary
      cd07685
      Location:7 → 243
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:455 → 539
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:566 → 817
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

    3. XM_040680399.2 → XP_040536333.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/TrEMBL
      A0A8V0X6E7
      Conserved Domains (3) summary
      cd07685
      Location:61 → 297
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:509 → 593
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:620 → 871
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

    4. XM_040680402.2 → XP_040536336.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      Q90778
      Conserved Domains (3) summary
      cd07685
      Location:7 → 243
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:455 → 539
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:566 → 817
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes

    5. XM_046925171.1 → XP_046781127.1  tyrosine-protein kinase Fes/Fps isoform X3

      UniProtKB/TrEMBL
      Q90778

    RNA

    1. XR_005853077.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001031571.1: Suppressed sequence

      Description
      NM_001031571.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version

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