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    NEDD9 neural precursor cell expressed, developmentally down-regulated 9 [ Gallus gallus (chicken) ]

    Gene ID: 395736, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NEDD9provided by CGNC
    Official Full Name
    neural precursor cell expressed, developmentally down-regulated 9provided by CGNC
    Primary source
    CGNC:49448
    See related
    Ensembl:ENSGALG00010010697
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See NEDD9 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (62754902..62849326)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (62703533..62797935)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene androgen dependent TFPI regulating protein Neighboring gene transmembrane protein 170B Neighboring gene uncharacterized LOC107051667 Neighboring gene uncharacterized LOC121109719 Neighboring gene small integral membrane protein 13 Neighboring gene ELOVL fatty acid elongase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The retinoic acid inducible Cas-family signaling protein Nedd9 regulates neural crest cell migration by modulating adhesion and actin dynamics. Aquino JB, et al. Neuroscience, 2009 Sep 15. PMID 19464348, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nedd9 promotes the migration of NCCs in a graded manner and suggest a role for RA in the control of Nedd9 expression levels.
      Title: The retinoic acid inducible Cas-family signaling protein Nedd9 regulates neural crest cell migration by modulating adhesion and actin dynamics.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enhancer of filamentation 1
    Names
    enhancer of filamentation 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      62754902..62849326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046930959.1 → XP_046786915.1  enhancer of filamentation 1 isoform X2

      UniProtKB/TrEMBL
      F1NW90

    2. XM_004939656.5 → XP_004939713.1  enhancer of filamentation 1 isoform X2

      UniProtKB/TrEMBL
      F1NW90
      Related
      ENSGALP00010014396.1, ENSGALT00010025490.1
      Conserved Domains (3) summary
      cd11550
      Location:394 → 555
      Serine_rich_NEDD9; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
      cd12002
      Location:4 → 60
      SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
      pfam12026
      Location:610 → 817
      DUF3513; Domain of unknown function (DUF3513)

    3. XM_418946.8 → XP_418946.4  enhancer of filamentation 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2TVN1
      Related
      ENSGALP00010014392.1, ENSGALT00010025482.1
      Conserved Domains (3) summary
      cd11550
      Location:397 → 558
      Serine_rich_NEDD9; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
      cd12002
      Location:7 → 63
      SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
      pfam12026
      Location:613 → 820
      DUF3513; Domain of unknown function (DUF3513)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      62703533..62797935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046911972.1 → XP_046767928.1  enhancer of filamentation 1 isoform X2

    2. XM_040662858.2 → XP_040518792.1  enhancer of filamentation 1 isoform X2

      Conserved Domains (3) summary
      cd11550
      Location:394 → 555
      Serine_rich_NEDD9; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
      cd11570
      Location:693 → 820
      FAT-like_NEDD9_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
      cd12002
      Location:4 → 60
      SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9

    3. XM_040662857.2 → XP_040518791.1  enhancer of filamentation 1 isoform X1

      Conserved Domains (3) summary
      cd11550
      Location:397 → 558
      Serine_rich_NEDD9; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
      cd11570
      Location:696 → 823
      FAT-like_NEDD9_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
      cd12002
      Location:7 → 63
      SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
    Nucleotide Protein Strain
    Heading Accession and Version

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