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    OCRL OCRL inositol polyphosphate-5-phosphatase [ Aquila chrysaetos chrysaetos ]

    Gene ID: 115333738, updated on 3-Aug-2024

    Summary

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    Gene symbol
    OCRL
    Gene description
    OCRL inositol polyphosphate-5-phosphatase
    See related
    Ensembl:ENSACCG00020007957
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Aquila chrysaetos chrysaetos (sub-species: chrysaetos)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Accipitrimorphae; Accipitriformes; Accipitridae; Accipitrinae; Aquila
    Orthologs
    human mouse all
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    Genomic context

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    See OCRL in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    101 current bAquChr1.4 (GCF_900496995.4) 21 NC_044024.1 (24142490..24165533, complement)

    Chromosome 21 - NC_044024.1Genomic Context describing neighboring genes Neighboring gene X-prolyl aminopeptidase 2 Neighboring gene apelin Neighboring gene ERCC excision repair 6 like, spindle assembly checkpoint helicase Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_044024.1 Chromosome 21 Reference bAquChr1.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables inositol phosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inositol polyphosphate 5-phosphatase OCRL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Aquila chrysaetos chrysaetos Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bAquChr1.4

    Genomic

    1. NC_044024.1 Reference bAquChr1.4

      Range
      24142490..24165533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_029997094.2 → XP_029852954.1  inositol polyphosphate 5-phosphatase OCRL isoform X2

      Conserved Domains (3) summary
      cd09093
      Location:238 → 531
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      cd04380
      Location:666 → 895
      RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
      pfam16726
      Location:17 → 115
      OCRL_clath_bd; Inositol polyphosphate 5-phosphatase clathrin binding domain

    2. XM_029997095.2 → XP_029852955.1  inositol polyphosphate 5-phosphatase OCRL isoform X3

      Conserved Domains (3) summary
      cd09093
      Location:239 → 532
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      cd04380
      Location:667 → 888
      RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
      pfam16726
      Location:17 → 116
      OCRL_clath_bd; Inositol polyphosphate 5-phosphatase clathrin binding domain

    3. XM_029997093.2 → XP_029852953.1  inositol polyphosphate 5-phosphatase OCRL isoform X1

      UniProtKB/TrEMBL
      A0A663EGW9
      Related
      ENSACCP00020011582.1
      Conserved Domains (3) summary
      cd09093
      Location:239 → 532
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      cd04380
      Location:667 → 896
      RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
      pfam16726
      Location:17 → 116
      OCRL_clath_bd; Inositol polyphosphate 5-phosphatase clathrin binding domain

    4. XM_041119056.1 → XP_040974990.1  inositol polyphosphate 5-phosphatase OCRL isoform X5

      Conserved Domains (3) summary
      cd09093
      Location:239 → 532
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      cd13382
      Location:12 → 113
      PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain
      cl02570
      Location:667 → 716
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    5. XM_029997096.2 → XP_029852956.1  inositol polyphosphate 5-phosphatase OCRL isoform X4

      UniProtKB/TrEMBL
      A0A663EIA1
      Related
      ENSACCP00020011594.1
      Conserved Domains (3) summary
      cd09093
      Location:239 → 532
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      pfam16726
      Location:17 → 116
      OCRL_clath_bd; Inositol polyphosphate 5-phosphatase clathrin binding domain
      cl02570
      Location:667 → 702
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    Nucleotide Protein
    Heading Accession and Version

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