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    pak3.L p21 protein (Cdc42/Rac)-activated kinase 3 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 378493, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pak3.L
    Official Full Name
    p21 protein (Cdc42/Rac)-activated kinase 3 L homeolog
    Primary source
    Xenbase:XB-GENE-961767
    Locus tag
    XELAEV_18038804mg
    See related
    EnsemblRapid:ENSXLAG00005011016 AllianceGenome:Xenbase:XB-GENE-961767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    bpak; pak3; PAK-3; XPak3; mrx30; mrx47; ophn3; cdkn1a; pak3-A; pak3beta
    Summary
    Predicted to enable several functions, including ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Acts upstream of or within several processes, including anterior neural plate formation; cement gland development; and negative regulation of neuroblast proliferation. Predicted to be located in cytoplasm. Is expressed in ectoderm and nervous system. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See pak3.L in Genome Data Viewer
    Location:
    chromosome: 8L
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (42870010..42981742)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (29703060..29815034)

    Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene AMMECR nuclear protein 1 L homeolog Neighboring gene chordin-like 1 L homeolog Neighboring gene calpain 6 L homeolog Neighboring gene doublecortin L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. XPak3 promotes cell cycle withdrawal during primary neurogenesis in Xenopus laevis. Souopgui J, et al. EMBO J, 2002 Dec 2. PMID 12456650, Free PMC Article
    2. Maturin is a novel protein required for differentiation during primary neurogenesis. Martinez-De Luna RI, et al. Dev Biol, 2013 Dec 1. PMID 24095902, Free PMC Article
    3. Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress. Wang F, et al. Sci Rep, 2018 Feb 8. PMID 29422626, Free PMC Article
    4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior neural plate formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cement gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural plate formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 3
    Names
    PAK3a protein
    PAK3d protein
    p21-activated kinase 3
    serine/threonine protein kinase (p21-activated kinase 3)
    NP_001079232.1
    XP_018084070.1
    XP_041427821.1
    XP_041427822.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085763.1 → NP_001079232.1  serine/threonine-protein kinase PAK 3

      See identical proteins and their annotated locations for NP_001079232.1

      Status: PROVISIONAL

      Source sequence(s)
      AF485330
      UniProtKB/Swiss-Prot
      Q8AXB4
      UniProtKB/TrEMBL
      B1GX83
      Related
      ENSXLAP00005032449.1, ENSXLAT00005033235.1
      Conserved Domains (3) summary
      cd06656
      Location:268 → 564
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      smart00220
      Location:288 → 539
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      42870010..42981742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041571888.1 → XP_041427822.1  serine/threonine-protein kinase PAK 3 isoform X1

      UniProtKB/TrEMBL
      A0A8J1LE63, B1GX83
      Conserved Domains (2) summary
      cd06656
      Location:278 → 574
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      cd01093
      Location:68 → 138
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    2. XM_041571887.1 → XP_041427821.1  serine/threonine-protein kinase PAK 3 isoform X1

      UniProtKB/TrEMBL
      A0A8J1LE63, B1GX83
      Related
      ENSXLAP00005032442.1, ENSXLAT00005033228.1
      Conserved Domains (2) summary
      cd06656
      Location:278 → 574
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      cd01093
      Location:68 → 138
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    3. XM_018228581.2 → XP_018084070.1  serine/threonine-protein kinase PAK 3 isoform X2

      UniProtKB/TrEMBL
      A0A974C7I0, B1GX82, B1GX83
      Related
      ENSXLAP00005032453.1, ENSXLAT00005033239.1
      Conserved Domains (3) summary
      cd06656
      Location:253 → 549
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      smart00220
      Location:273 → 524
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:69 → 124
      PBD; P21-Rho-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8AXB4.1 GenPept UniProtKB/Swiss-Prot:Q8AXB4

    Gene LinkOut

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