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    Ap2a1 adaptor related protein complex 2 subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308578, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ap2a1provided by RGD
    Official Full Name
    adaptor related protein complex 2 subunit alpha 1provided by RGD
    Primary source
    RGD:1306254
    See related
    EnsemblRapid:ENSRNOG00000026243 AllianceGenome:RGD:1306254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable clathrin adaptor activity; low-density lipoprotein particle receptor binding activity; and protein kinase binding activity. Involved in positive regulation of neuron projection development and positive regulation of receptor-mediated endocytosis. Located in apical plasma membrane; basolateral plasma membrane; and clathrin-coated vesicle. Part of protein-containing complex. Is active in synaptic vesicle. Orthologous to human AP2A1 (adaptor related protein complex 2 subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 124.7), Kidney (RPKM 81.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap2a1 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104520789..104550655, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95384306..95414170, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100896582..100926443, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene PTOV1, extended AT-hook containing adaptor protein Neighboring gene mediator complex subunit 25 Neighboring gene fuzzy planar cell polarity protein Neighboring gene transfer RNA proline (anticodon AGG) 45 Neighboring gene testis-specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The role of endocytic l1 trafficking in polarized adhesion and migration of nerve growth cones. Kamiguchi H, et al. J Neurosci, 2001 Dec 1. PMID 11717353, Free PMC Article
    2. Evidence on differential role for alpha 1 and alpha 2 subtypes of AP-2 adaptin in the central nervous system. Capella P, et al. Neurosci Lett, 2023 Jun 21. PMID 37127089
    3. Co-localization of rab4 with endocytosis-related proteins in the rat parotid glands. Nashida T, et al. Arch Histol Cytol, 2003 Mar. PMID 12703553
    4. The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminals. Chen H, et al. J Biol Chem, 1999 Feb 5. PMID 9920862
    5. Inhibition of receptor-mediated endocytosis by the amphiphysin SH3 domain. Wigge P, et al. Curr Biol, 1997 Aug 1. PMID 9259551

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evidence on differential role for alpha 1 and alpha 2 subtypes of AP-2 adaptin in the central nervous system.
      Title: Evidence on differential role for alpha 1 and alpha 2 subtypes of AP-2 adaptin in the central nervous system.
    2. SP-A transiently enhances the basal protein expression of CHC and alpha-adaptin.
      Title: Surfactant Protein A Enhances Constitutive Immune Functions of Clathrin Heavy Chain and Clathrin Adaptor Protein 2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-2 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in filopodium tip ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of membrane coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic endocytic zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AP-2 complex subunit alpha-1
    Names
    adaptor protein complex AP-2, alpha 1 subunit
    adaptor-related protein complex 2, alpha 1 subunit
    alpha-adaptin A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395092.1 → NP_001382021.1  AP-2 complex subunit alpha-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JAU3
      Related
      ENSRNOP00000020304.7, ENSRNOT00000020304.8
      Conserved Domains (3) summary
      smart00809
      Location:755 → 858
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam02296
      Location:864 → 972
      Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
      pfam01602
      Location:29 → 591
      Adaptin_N; Adaptin N terminal region

    2. NM_001395093.1 → NP_001382022.1  AP-2 complex subunit alpha-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D3ZUY8
      Conserved Domains (4) summary
      smart00809
      Location:733 → 836
      Alpha_adaptinC2; Adaptin C-terminal domain
      sd00044
      Location:332 → 355
      HEAT; HEAT repeat [structural motif]
      pfam02296
      Location:842 → 950
      Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
      pfam01602
      Location:29 → 591
      Adaptin_N; Adaptin N terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104520789..104550655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261978.1 → XP_063118048.1  AP-2 complex subunit alpha-1 isoform X3

      UniProtKB/TrEMBL
      D3ZUY8
      Related
      ENSRNOP00000087357.1, ENSRNOT00000097722.2

    2. XM_063261976.1 → XP_063118046.1  AP-2 complex subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A6JAU3
      Related
      ENSRNOP00000086051.1, ENSRNOT00000101662.2

    3. XM_063261974.1 → XP_063118044.1  AP-2 complex subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      D3ZUY8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107511.2: Suppressed sequence

      Description
      NM_001107511.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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