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    Unc5a unc-5 netrin receptor A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60629, updated on 9-Dec-2024

    Summary

    Official Symbol
    Unc5aprovided by RGD
    Official Full Name
    unc-5 netrin receptor Aprovided by RGD
    Primary source
    RGD:621755
    See related
    EnsemblRapid:ENSRNOG00000059840 AllianceGenome:RGD:621755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Unc5h1
    Summary
    Enables netrin receptor activity. Involved in axon guidance and netrin-activated signaling pathway. Located in neuron projection membrane and neuronal cell body membrane. Orthologous to human UNC5A (unc-5 netrin receptor A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 33.6), Adrenal (RPKM 7.7) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Unc5a in Genome Data Viewer
    Location:
    17p14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9620005..9675794, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9614841..9670558, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10152949..10208599, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 346 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene hexokinase 3 Neighboring gene uncharacterized LOC120097834 Neighboring gene tetraspanin 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables netrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables netrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables netrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in anterior/posterior axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in anterior/posterior axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within anterior/posterior axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in netrin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in netrin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in neuronal cell body membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    netrin receptor UNC5A
    Names
    protein unc-5 homolog 1
    protein unc-5 homolog A
    transmembrane receptor Unc5H1
    unc-5 homolog 1
    unc-5 homolog A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022206.2NP_071542.2  netrin receptor UNC5A precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      O08721
      UniProtKB/TrEMBL
      A0A8I5YBB0
      Related
      ENSRNOP00000076444.2, ENSRNOT00000107999.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      9620005..9675794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771505.3XP_008769727.1  netrin receptor UNC5A isoform X1

      UniProtKB/Swiss-Prot
      O08721
      UniProtKB/TrEMBL
      A0A0G2JZN2
      Related
      ENSRNOP00000071115.3, ENSRNOT00000087397.3
      Conserved Domains (5) summary
      smart00218
      Location:439542
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00209
      Location:254293
      TSP1; Thrombospondin type 1 repeats
      pfam07679
      Location:151239
      I-set; Immunoglobulin I-set domain
      cd08800
      Location:755838
      Death_UNC5A; Death domain found in Uncoordinated-5A
      cl11960
      Location:153239
      Ig; Immunoglobulin domain

    RNA

    1. XR_005495326.2 RNA Sequence