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    PRR33 proline rich 33 [ Homo sapiens (human) ]

    Gene ID: 102724536, updated on 4-Jan-2025

    Summary

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    Official Symbol
    PRR33provided by HGNC
    Official Full Name
    proline rich 33provided by HGNC
    Primary source
    HGNC:HGNC:35118
    See related
    Ensembl:ENSG00000283787 AllianceGenome:HGNC:35118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C11orf89
    Summary
    Predicted to act upstream of or within response to wounding. [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    mouse all
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    Genomic context

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    See PRR33 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1887987..1917708, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1973881..1981781, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1909308..1913125, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene microRNA 4298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1891831-1892369 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1892370-1892907 Neighboring gene lymphocyte specific protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1896777-1897673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1897674-1898570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4294 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1908437-1908603 Neighboring gene microRNA 7847 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:1918050-1919249 Neighboring gene long intergenic non-protein coding RNA 1150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1927717-1928218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1928219-1928718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4295 Neighboring gene troponin T3, fast skeletal type Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1956346-1956534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1956988-1957585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1970491-1971228 Neighboring gene small nucleolar RNA, C/D box 131 Neighboring gene mitochondrial ribosomal protein L23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study identifies novel breast cancer susceptibility loci. Easton DF, et al. Nature, 2007 Jun 28. PMID 17529967, Free PMC Article
    2. Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. Lindström S, et al. Nat Commun, 2014 Oct 24. PMID 25342443, Free PMC Article
    3. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Michailidou K, et al. Nat Genet, 2013 Apr. PMID 23535729, Free PMC Article
    4. Human chromosome 11 DNA sequence and analysis including novel gene identification. Taylor TD, et al. Nature, 2006 Mar 23. PMID 16554811

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
    EBI GWAS Catalog
    Genome-wide association study identifies novel breast cancer susceptibility loci.
    EBI GWAS Catalog
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    General protein information

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    Preferred Names
    proline-rich protein 33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395380.1 → NP_001382309.1  proline-rich protein 33

      Status: VALIDATED

      Source sequence(s)
      AC051649
      Consensus CDS
      CCDS91402.1
      UniProtKB/TrEMBL
      A0A1W2PPC1
      Related
      ENSP00000491327.1, ENST00000640310.2
      Conserved Domains (1) summary
      PRK12323
      Location:167 → 403
      PRK12323; DNA polymerase III subunit gamma/tau

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      1887987..1917708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426236.1 → XP_047282192.1  proline-rich protein 33 isoform X1

      UniProtKB/TrEMBL
      A0A1W2PPC1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160004.1 Reference GRCh38.p14 PATCHES

      Range
      78490..86565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332445.1 → XP_054188420.1  proline-rich protein 33 isoform X1

      UniProtKB/TrEMBL
      A0A1W2PPC1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      1973881..1981781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367441.1 → XP_054223416.1  proline-rich protein 33 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MZF0.2 GenPept UniProtKB/Swiss-Prot:A8MZF0

    Gene LinkOut

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