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    mboat4 membrane bound O-acyltransferase domain containing 4 [ Danio rerio (zebrafish) ]

    Gene ID: 795709, updated on 4-Jan-2025

    Summary

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    Official Symbol
    mboat4provided by ZNC
    Official Full Name
    membrane bound O-acyltransferase domain containing 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090421-3
    See related
    Ensembl:ENSDARG00000052110 AllianceGenome:ZFIN:ZDB-GENE-090421-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Enables serine O-acyltransferase activity. Involved in peptidyl-serine octanoylation. Acts upstream of or within response to food. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including digestive system; eye; heart; integument; and pleuroperitoneal region. Orthologous to human MBOAT4 (membrane bound O-acyltransferase domain containing 4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See mboat4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (66156986..66170288, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (65478012..65481310, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene Janus kinase 2b Neighboring gene zgc:114041 Neighboring gene glycine dehydrogenase (decarboxylating) Neighboring gene coenzyme Q2 4-hydroxybenzoate polyprenyltransferase Neighboring gene major facilitator superfamily domain containing 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Brain transcriptome profile after CRISPR-induced ghrelin mutations in zebrafish. Blanco AM, et al. Fish Physiol Biochem, 2020 Feb. PMID 31673996
    2. Ghrelin O-Acyl Transferase in Zebrafish Is an Evolutionarily Conserved Peptide Upregulated During Calorie Restriction. Hatef A, et al. Zebrafish, 2015 Oct. PMID 26226634, Free PMC Article
    3. Ghrelin octanoylation mediated by an orphan lipid transferase. Gutierrez JA, et al. Proc Natl Acad Sci U S A, 2008 Apr 29. PMID 18443287, Free PMC Article
    4. Analysis of the Long-Lived Responses Induced by Immunostimulants and Their Effects on a Viral Infection in Zebrafish (Danio rerio). Álvarez-Rodríguez M, et al. Front Immunol, 2018. PMID 30038625, Free PMC Article
    5. Probiotic treatment reduces appetite and glucose level in the zebrafish model. Falcinelli S, et al. Sci Rep, 2016 Jan 5. PMID 26727958, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidyl-serine octanoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-serine octanoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to food IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ghrelin O-acyltransferase
    Names
    GOAT
    NP_001116416.1
    XP_021332001.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122944.1 → NP_001116416.1  ghrelin O-acyltransferase

      See identical proteins and their annotated locations for NP_001116416.1

      Status: PROVISIONAL

      Source sequence(s)
      EU518498
      UniProtKB/Swiss-Prot
      B1Q006
      Related
      ENSDARP00000068385.4, ENSDART00000073895.5
      Conserved Domains (1) summary
      cl00738
      Location:19 → 399
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      66156986..66170288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476326.2 → XP_021332001.1  ghrelin O-acyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q916
      Conserved Domains (1) summary
      cl00738
      Location:3 → 352
      MBOAT; membrane-bound O-acyltransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1Q006.1 GenPept UniProtKB/Swiss-Prot:B1Q006

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.