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    ZSCAN31 zinc finger and SCAN domain containing 31 [ Homo sapiens (human) ]

    Gene ID: 64288, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZSCAN31provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 31provided by HGNC
    Primary source
    HGNC:HGNC:14097
    See related
    Ensembl:ENSG00000235109 MIM:610794; AllianceGenome:HGNC:14097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF323; ZNF310P; ZNF20-Lp
    Summary
    This gene encodes a protein containing multiple C2H2-type zinc finger motifs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 2.2), testis (RPKM 2.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZSCAN31 in Genome Data Viewer
    Location:
    6p22.1; 6p22.3-p22.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (28324737..28356271, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (28196485..28227848, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28292514..28324048, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17044 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:28249721-28249897 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:28251848-28252055 Neighboring gene piggyBac transposable element derived 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28278749-28279250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28279251-28279750 Neighboring gene SMIM15 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28321865-28322364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24355 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:28324191-28325095 Neighboring gene zinc finger with KRAB and SCAN domains 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24356 Neighboring gene zinc finger and SCAN domain containing 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17045 Neighboring gene uncharacterized LOC105374998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24357

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23407, FLJ41286

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger and SCAN domain-containing protein 31
    Names
    zinc finger protein 323

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135215.1NP_001128687.1  zinc finger and SCAN domain-containing protein 31 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) initiates transcription from an alternate promoter and differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 7 encode the same isoform (1).
      Source sequence(s)
      AF513019, AK095261, AL021997
      Consensus CDS
      CCDS4649.1
      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
      Related
      ENSP00000390076.1, ENST00000414429.5
      Conserved Domains (6) summary
      smart00431
      Location:35146
      SCAN; leucine rich region
      COG5048
      Location:156397
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:239261
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:35123
      SCAN; SCAN domain
      pfam13465
      Location:310332
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001135216.1NP_001128688.1  zinc finger and SCAN domain-containing protein 31 isoform 1

      See identical proteins and their annotated locations for NP_001128688.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 7 encode the same isoform (1).
      Source sequence(s)
      AF513019, AL833617, BC008490
      Consensus CDS
      CCDS4649.1
      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
      Related
      ENSP00000413705.1, ENST00000439158.5
      Conserved Domains (6) summary
      smart00431
      Location:35146
      SCAN; leucine rich region
      COG5048
      Location:156397
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:239261
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:35123
      SCAN; SCAN domain
      pfam13465
      Location:310332
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001243241.1NP_001230170.1  zinc finger and SCAN domain-containing protein 31 isoform 1

      See identical proteins and their annotated locations for NP_001230170.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 7 encode the same isoform (1).
      Source sequence(s)
      BC065241, DA875036, DN995648
      Consensus CDS
      CCDS4649.1
      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
      Conserved Domains (6) summary
      smart00431
      Location:35146
      SCAN; leucine rich region
      COG5048
      Location:156397
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:239261
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:35123
      SCAN; SCAN domain
      pfam13465
      Location:310332
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001243242.1NP_001230171.1  zinc finger and SCAN domain-containing protein 31 isoform 2

      See identical proteins and their annotated locations for NP_001230171.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream, in-frame start codon, compared to variant 1. Variants 5, 6 and 8 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      BC065241, DA875036, DA879276
      Consensus CDS
      CCDS59001.1
      UniProtKB/Swiss-Prot
      Q96LW9
      Related
      ENSP00000480254.1, ENST00000611469.4
      Conserved Domains (2) summary
      COG5048
      Location:79238
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:82102
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. NM_001243243.1NP_001230172.1  zinc finger and SCAN domain-containing protein 31 isoform 2

      See identical proteins and their annotated locations for NP_001230172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream, in-frame start codon, compared to variant 1. Variants 5, 6 and 8 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL833617, BC065241
      Consensus CDS
      CCDS59001.1
      UniProtKB/Swiss-Prot
      Q96LW9
      Related
      ENSP00000402937.1, ENST00000446474.5
      Conserved Domains (2) summary
      COG5048
      Location:79238
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:82102
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. NM_001243244.1NP_001230173.1  zinc finger and SCAN domain-containing protein 31 isoform 2

      See identical proteins and their annotated locations for NP_001230173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks a portion of the 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. Variants 5, 6 and 8 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      BC065241, DA875036
      Consensus CDS
      CCDS59001.1
      UniProtKB/Swiss-Prot
      Q96LW9
      Related
      ENSP00000391235.1, ENST00000435857.5
      Conserved Domains (2) summary
      COG5048
      Location:79238
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:82102
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. NM_030899.5NP_112161.3  zinc finger and SCAN domain-containing protein 31 isoform 1

      See identical proteins and their annotated locations for NP_112161.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, 3, 4 and 7 encode the same isoform (1).
      Source sequence(s)
      AL021997
      Consensus CDS
      CCDS4649.1
      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
      Related
      ENSP00000345339.6, ENST00000344279.11
      Conserved Domains (6) summary
      smart00431
      Location:35146
      SCAN; leucine rich region
      COG5048
      Location:156397
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:239261
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:35123
      SCAN; SCAN domain
      pfam13465
      Location:310332
      zf-H2C2_2; Zinc-finger double domain
    8. NM_145909.3NP_665916.1  zinc finger and SCAN domain-containing protein 31 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 7 encode the same isoform (1).
      Source sequence(s)
      AF513019, AL021997
      Consensus CDS
      CCDS4649.1
      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
      Related
      ENSP00000380050.2, ENST00000396838.6
      Conserved Domains (6) summary
      smart00431
      Location:35146
      SCAN; leucine rich region
      COG5048
      Location:156397
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:239261
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:35123
      SCAN; SCAN domain
      pfam13465
      Location:310332
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      28324737..28356271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446521.2XP_024302289.1  zinc finger and SCAN domain-containing protein 31 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:122281
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:125145
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_011514808.4XP_011513110.1  zinc finger and SCAN domain-containing protein 31 isoform X1

      See identical proteins and their annotated locations for XP_011513110.1

      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
      Conserved Domains (6) summary
      smart00431
      Location:35146
      SCAN; leucine rich region
      COG5048
      Location:156397
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:239261
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:35123
      SCAN; SCAN domain
      pfam13465
      Location:310332
      zf-H2C2_2; Zinc-finger double domain
    3. XM_047419257.1XP_047275213.1  zinc finger and SCAN domain-containing protein 31 isoform X1

      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
    4. XM_024446522.2XP_024302290.1  zinc finger and SCAN domain-containing protein 31 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:79238
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:82102
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. XM_005249296.6XP_005249353.1  zinc finger and SCAN domain-containing protein 31 isoform X1

      See identical proteins and their annotated locations for XP_005249353.1

      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
      Conserved Domains (6) summary
      smart00431
      Location:35146
      SCAN; leucine rich region
      COG5048
      Location:156397
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:239261
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:35123
      SCAN; SCAN domain
      pfam13465
      Location:310332
      zf-H2C2_2; Zinc-finger double domain
    6. XM_005249295.2XP_005249352.1  zinc finger and SCAN domain-containing protein 31 isoform X1

      See identical proteins and their annotated locations for XP_005249352.1

      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
      Conserved Domains (6) summary
      smart00431
      Location:35146
      SCAN; leucine rich region
      COG5048
      Location:156397
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:239261
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:35123
      SCAN; SCAN domain
      pfam13465
      Location:310332
      zf-H2C2_2; Zinc-finger double domain
    7. XM_047419255.1XP_047275211.1  zinc finger and SCAN domain-containing protein 31 isoform X1

      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
    8. XM_047419254.1XP_047275210.1  zinc finger and SCAN domain-containing protein 31 isoform X1

      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
    9. XM_047419256.1XP_047275212.1  zinc finger and SCAN domain-containing protein 31 isoform X1

      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
    10. XM_047419253.1XP_047275209.1  zinc finger and SCAN domain-containing protein 31 isoform X1

      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
    11. XM_011514809.2XP_011513111.1  zinc finger and SCAN domain-containing protein 31 isoform X1

      See identical proteins and their annotated locations for XP_011513111.1

      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
      Conserved Domains (6) summary
      smart00431
      Location:35146
      SCAN; leucine rich region
      COG5048
      Location:156397
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:239261
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:35123
      SCAN; SCAN domain
      pfam13465
      Location:310332
      zf-H2C2_2; Zinc-finger double domain
    12. XM_011514812.3XP_011513114.1  zinc finger and SCAN domain-containing protein 31 isoform X1

      See identical proteins and their annotated locations for XP_011513114.1

      UniProtKB/Swiss-Prot
      Q6P178, Q8WWS5, Q96LW9
      Conserved Domains (6) summary
      smart00431
      Location:35146
      SCAN; leucine rich region
      COG5048
      Location:156397
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:241261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:239261
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:35123
      SCAN; SCAN domain
      pfam13465
      Location:310332
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_007059330.1 RNA Sequence

    2. XR_002956295.2 RNA Sequence

    3. XR_007059331.1 RNA Sequence

    4. XR_002956296.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      28196485..28227848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356233.1XP_054212208.1  zinc finger and SCAN domain-containing protein 31 isoform X2

    2. XM_054356232.1XP_054212207.1  zinc finger and SCAN domain-containing protein 31 isoform X1

    3. XM_054356231.1XP_054212206.1  zinc finger and SCAN domain-containing protein 31 isoform X1

    4. XM_054356236.1XP_054212211.1  zinc finger and SCAN domain-containing protein 31 isoform X3

      UniProtKB/TrEMBL
      Q8N3P9
    5. XM_054356227.1XP_054212202.1  zinc finger and SCAN domain-containing protein 31 isoform X1

    6. XM_054356234.1XP_054212209.1  zinc finger and SCAN domain-containing protein 31 isoform X3

      UniProtKB/TrEMBL
      Q8N3P9
    7. XM_054356226.1XP_054212201.1  zinc finger and SCAN domain-containing protein 31 isoform X1

    8. XM_054356222.1XP_054212197.1  zinc finger and SCAN domain-containing protein 31 isoform X1

    9. XM_054356235.1XP_054212210.1  zinc finger and SCAN domain-containing protein 31 isoform X3

      UniProtKB/TrEMBL
      Q8N3P9
    10. XM_054356225.1XP_054212200.1  zinc finger and SCAN domain-containing protein 31 isoform X1

    11. XM_054356223.1XP_054212198.1  zinc finger and SCAN domain-containing protein 31 isoform X1

    12. XM_054356228.1XP_054212203.1  zinc finger and SCAN domain-containing protein 31 isoform X1

    13. XM_054356224.1XP_054212199.1  zinc finger and SCAN domain-containing protein 31 isoform X1

    14. XM_054356229.1XP_054212204.1  zinc finger and SCAN domain-containing protein 31 isoform X1

    15. XM_054356230.1XP_054212205.1  zinc finger and SCAN domain-containing protein 31 isoform X1

    RNA

    1. XR_008487429.1 RNA Sequence

    2. XR_008487426.1 RNA Sequence

    3. XR_008487428.1 RNA Sequence

    4. XR_008487427.1 RNA Sequence