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    TRIO trio Rho guanine nucleotide exchange factor [ Centrocercus urophasianus (Greater sage-grouse) ]

    Gene ID: 122155050, updated on 22-Mar-2024

    Summary

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    Gene symbol
    TRIO
    Gene description
    trio Rho guanine nucleotide exchange factor
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Centrocercus urophasianus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Tetraoninae; Centrocercus
    Orthologs
    human mouse all
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    Genomic context

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    See TRIO in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    100 current USGS_Curo_1.0 (GCF_019232065.1) Unplaced Scaffold NW_024884253.1 (69669851..69893873)

    NW_024884253.1Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 5 Neighboring gene uncharacterized LOC122171574 Neighboring gene OTU deubiquitinase with linear linkage specificity like Neighboring gene OTU deubiquitinase with linear linkage specificity

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_024884253 Unplaced Scaffold Reference USGS_Curo_1.0

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    triple functional domain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Centrocercus urophasianus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference USGS_Curo_1.0

    Genomic

    1. NW_024884253.1 Reference USGS_Curo_1.0

      Range
      69669851..69893873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042808742.1 → XP_042664676.1  triple functional domain protein isoform X1

      Conserved Domains (10) summary
      smart00150
      Location:1131 → 1231
      SPEC; Spectrin repeats
      cd11852
      Location:1647 → 1706
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2534 → 2592
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00409
      Location:2671 → 2755
      IG; Immunoglobulin
      smart00516
      Location:57 → 192
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1958 → 2131
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:555 → 771
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1460 → 1582
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2136 → 2274
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:2767 → 3029
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein

    2. XM_042808744.1 → XP_042664678.1  triple functional domain protein isoform X3

      Conserved Domains (7) summary
      smart00150
      Location:1084 → 1184
      SPEC; Spectrin repeats
      cd11852
      Location:1600 → 1659
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:10 → 145
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1911 → 2084
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:508 → 724
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1413 → 1535
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2089 → 2227
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

    3. XM_042808745.1 → XP_042664679.1  triple functional domain protein isoform X4

      Conserved Domains (6) summary
      smart00150
      Location:1084 → 1184
      SPEC; Spectrin repeats
      cd11852
      Location:1600 → 1659
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:10 → 145
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1236 → 1406
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:508 → 724
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1413 → 1535
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    4. XM_042808743.1 → XP_042664677.1  triple functional domain protein isoform X2

      Conserved Domains (9) summary
      smart00150
      Location:568 → 668
      SPEC; Spectrin repeats
      cd11852
      Location:1084 → 1143
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:1971 → 2029
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00409
      Location:2108 → 2192
      IG; Immunoglobulin
      cd00160
      Location:1395 → 1568
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:2 → 208
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:897 → 1019
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:1573 → 1711
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:2204 → 2466
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    Nucleotide Protein
    Heading Accession and Version

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