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    VAV1 vav guanine nucleotide exchange factor 1 [ Prionailurus bengalensis (leopard cat) ]

    Gene ID: 122486803, updated on 22-Mar-2024

    Summary

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    Gene symbol
    VAV1
    Gene description
    vav guanine nucleotide exchange factor 1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Prionailurus bengalensis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Prionailurus
    Orthologs
    human mouse all
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    Genomic context

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    See VAV1 in Genome Data Viewer
    Location:
    chromosome: A2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    100 current Fcat_Pben_1.1_paternal_pri (GCF_016509475.1) A2 NC_057348.1 (5039600..5089193)

    Chromosome A2 - NC_057348.1Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene SH2 domain containing 3A Neighboring gene adhesion G protein-coupled receptor E1 Neighboring gene adhesion G protein-coupled receptor E4-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_057348.1 Chromosome A2 Reference Fcat_Pben_1.1_paternal_pri Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proto-oncogene vav

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Prionailurus bengalensis Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Fcat_Pben_1.1_paternal_pri Primary Assembly

    Genomic

    1. NC_057348.1 Reference Fcat_Pben_1.1_paternal_pri Primary Assembly

      Range
      5039600..5089193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_043586389.1 → XP_043442324.1  proto-oncogene vav isoform X2

      Conserved Domains (7) summary
      cd10405
      Location:666 → 768
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:788 → 841
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:597 → 659
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:196 → 372
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:386 → 509
      PH_Vav; Vav pleckstrin homology (PH) domain
      cd21262
      Location:2 → 121
      CH_VAV1; calponin homology (CH) domain found in VAV1 protein
      cd20867
      Location:511 → 567
      C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

    2. XM_043586390.1 → XP_043442325.1  proto-oncogene vav isoform X3

      Conserved Domains (7) summary
      cd10405
      Location:666 → 768
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:787 → 840
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:597 → 659
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:196 → 372
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:386 → 509
      PH_Vav; Vav pleckstrin homology (PH) domain
      cd21262
      Location:2 → 121
      CH_VAV1; calponin homology (CH) domain found in VAV1 protein
      cd20867
      Location:511 → 567
      C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

    3. XM_043586391.1 → XP_043442326.1  proto-oncogene vav isoform X4

      Conserved Domains (7) summary
      cd10405
      Location:666 → 768
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:786 → 839
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:597 → 659
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:196 → 372
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:386 → 509
      PH_Vav; Vav pleckstrin homology (PH) domain
      cd21262
      Location:2 → 121
      CH_VAV1; calponin homology (CH) domain found in VAV1 protein
      cd20867
      Location:511 → 567
      C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

    4. XM_043586387.1 → XP_043442322.1  proto-oncogene vav isoform X1

      Conserved Domains (7) summary
      cd10405
      Location:666 → 768
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:789 → 842
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:597 → 659
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:196 → 372
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:386 → 509
      PH_Vav; Vav pleckstrin homology (PH) domain
      cd21262
      Location:2 → 121
      CH_VAV1; calponin homology (CH) domain found in VAV1 protein
      cd20867
      Location:511 → 567
      C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

    5. XM_043586394.1 → XP_043442329.1  proto-oncogene vav isoform X7

      Conserved Domains (7) summary
      smart00109
      Location:504 → 551
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd10405
      Location:653 → 755
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:775 → 828
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:584 → 646
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:196 → 372
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:386 → 496
      PH_Vav; Vav pleckstrin homology (PH) domain
      cl00030
      Location:18 → 102
      CH_SF; calponin homology (CH) domain superfamily

    6. XM_043586395.1 → XP_043442330.1  proto-oncogene vav isoform X8

      Conserved Domains (7) summary
      smart00109
      Location:504 → 551
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd10405
      Location:653 → 755
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:774 → 827
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:584 → 646
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:196 → 372
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:386 → 496
      PH_Vav; Vav pleckstrin homology (PH) domain
      cl00030
      Location:18 → 102
      CH_SF; calponin homology (CH) domain superfamily

    7. XM_043586396.1 → XP_043442331.1  proto-oncogene vav isoform X9

      Conserved Domains (7) summary
      smart00109
      Location:504 → 551
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd10405
      Location:653 → 755
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:773 → 826
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:584 → 646
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:196 → 372
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:386 → 496
      PH_Vav; Vav pleckstrin homology (PH) domain
      cl00030
      Location:18 → 102
      CH_SF; calponin homology (CH) domain superfamily

    8. XM_043586393.1 → XP_043442328.1  proto-oncogene vav isoform X6

      Conserved Domains (7) summary
      cd10405
      Location:653 → 755
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:776 → 829
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:584 → 646
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:196 → 372
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:386 → 496
      PH_Vav; Vav pleckstrin homology (PH) domain
      cd21262
      Location:2 → 121
      CH_VAV1; calponin homology (CH) domain found in VAV1 protein
      cd20867
      Location:498 → 554
      C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

    9. XM_043586392.1 → XP_043442327.1  proto-oncogene vav isoform X5

      Conserved Domains (6) summary
      smart00109
      Location:526 → 573
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd10405
      Location:675 → 777
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:795 → 848
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:606 → 668
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:205 → 381
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:395 → 518
      PH_Vav; Vav pleckstrin homology (PH) domain
    Nucleotide Protein
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