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    Retreg3 reticulophagy regulator family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360632, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Retreg3provided by RGD
    Official Full Name
    reticulophagy regulator family member 3provided by RGD
    Primary source
    RGD:1561189
    See related
    EnsemblRapid:ENSRNOG00000020056 AllianceGenome:RGD:1561189
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam134c; RGD1561189
    Summary
    Predicted to enable endoplasmic reticulum-autophagosome adaptor activity. Predicted to be involved in endoplasmic reticulum tubular network organization and positive regulation of neuron projection development. Predicted to act upstream of or within collagen catabolic process; endoplasmic reticulum organization; and reticulophagy. Predicted to be located in endoplasmic reticulum tubular network. Predicted to be part of protein-containing complex. Orthologous to human RETREG3 (reticulophagy regulator family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 225.8), Spleen (RPKM 189.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Retreg3 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86529048..86552873, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86028767..86052575, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89006595..89030595, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Coenzyme A synthase Neighboring gene MAX dimerization protein MLX Neighboring gene PSMC3 interacting protein Neighboring gene uncharacterized LOC134480875 Neighboring gene tubulin, gamma 1 Neighboring gene tubulin, gamma 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons. Wang JL, et al. Gene, 2013 Oct 15. PMID 23939472
    2. ZMPSTE24 defends against influenza and other pathogenic viruses. Fu B, et al. J Exp Med, 2017 Apr 3. PMID 28246125, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endoplasmic reticulum-autophagosome adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within reticulophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reticulophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    reticulophagy regulator 3
    Names
    family with sequence similarity 134, member C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135804.1 → NP_001129276.1  reticulophagy regulator 3

      See identical proteins and their annotated locations for NP_001129276.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166581
      UniProtKB/TrEMBL
      A6HJ86, B2GV94
      Related
      ENSRNOP00000027217.3, ENSRNOT00000027217.8
      Conserved Domains (1) summary
      cd22562
      Location:41 → 232
      RETR3_RHD; N-terminal reticulon-homology domain of Reticulophagy regulator 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86529048..86552873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086406.1 → XP_038942334.1  reticulophagy regulator 3 isoform X1

      Conserved Domains (1) summary
      cl41772
      Location:1 → 51
      Arl6IP1_RETR3-like; ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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