Mboat4 membrane bound O-acyltransferase domain containing 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mboat4provided by RGD
Official Full Name: membrane bound O-acyltransferase domain containing 4provided by RGD
Primary source: RGD:1566335
See related: EnsemblRapid:ENSRNOG00000030102 AllianceGenome:RGD:1566335
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566335
Summary: Enables serine O-acyltransferase activity. Involved in peptidyl-serine octanoylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human MBOAT4 (membrane bound O-acyltransferase domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 2.2), Muscle (RPKM 0.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (64765151..64780545, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (58064178..58077523, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (61782699..61795414, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ghrelin-O-acyltransferase (GOAT) acylates ghrelin in the hippocampus.
Title: Ghrelin-O-acyltransferase (GOAT) acylates ghrelin in the hippocampus.
GOAT immunoreactivity is aggregated at the base of the dentate granule cell layer in the rat. This immunoreactivity was not affected by the pharmacological inhibition of GHSR1a or the metabolic state-dependent fluctuation of systemic ghrelin levels.
Title: Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus.
Expression of hypothalamic ghrelin O-acyltransferase have an effect on body mass of rats fed a high-fat diet.
Title: Knockdown of central ghrelin O-acyltransferase by vivo-morpholino reduces body mass of rats fed a high-fat diet.
Ghrelin O-acyltransferase is present in murine pancreatic islet cells and that insulin inhibits the expression of ghrelin O-acyltransferase by the mediation of mTOR signaling.
Title: Modulation of ghrelin O-acyltransferase expression in pancreatic islets.
Ghrelin-O-acyltransferase (GOAT) mRNA in the stomach was up-regulated 21-fold in adult rats compared to young rats and 14-fold compared to adult dietary restriction rats.
Title: Long-term dietary restriction influences plasma ghrelin and GOAT mRNA level in rats.
These data suggest species differences between rats and mice in gastric GOAT expression perhaps resulting in a different role of the MBOAT4 enzyme in the rat stomach.
Title: Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa.
The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin.
Title: Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid.
findings suggest that increased GOAT mRNA levels may have a role in mediating the physiological responses to chronic undernutrition and could represent an adaptive response to prevent long-lasting alterations in energy balance and body weight homeostasis
Title: Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups	ISO Inferred from Sequence Orthology more info
enables serine O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine octanoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine octanoylation	ISO Inferred from Sequence Orthology more info
involved_in protein acylation	ISO Inferred from Sequence Orthology more info
involved_in protein decanoylation	ISO Inferred from Sequence Orthology more info
involved_in protein octanoylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ghrelin O-acyltransferase

Names: membrane-bound O-acyltransferase domain-containing protein 4

NP_001100787.2

EC 2.3.1.-

XP_017455622.1

EC 2.3.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107317.3 → NP_001100787.2 ghrelin O-acyltransferase

See identical proteins and their annotated locations for NP_001100787.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

B1Q005

Related

ENSRNOP00000046106.3, ENSRNOT00000042003.5

Conserved Domains (1) summary

cl00738
Location:96 → 349

MBOAT; MBOAT, membrane-bound O-acyltransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

64765151..64780545 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017600133.3 → XP_017455622.1 ghrelin O-acyltransferase isoform X1

UniProtKB/Swiss-Prot

B1Q005

Conserved Domains (1) summary

cl00738
Location:96 → 349

MBOAT; MBOAT, membrane-bound O-acyltransferase family