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    Mlp60A Muscle LIM protein at 60A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mlp60Aprovided by FlyBase
    Official Full Name
    Muscle LIM protein at 60Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259209
    Locus tag
    Dmel_CG42309
    See related
    AllianceGenome:FB:FBgn0259209
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE14544; BcDNA:RH74176; CG30174; CG30179; CG3220; CG33149; CG42309; DLim-2; Dmel\CG42309; DmLIM-2; DMlp1; DMLP1; dMlp60A; FBgn0259209; MLIM 60A; MLP; Mlp1; MLP1; Mlp60; MLP60A
    Old locus tag
    Dmel_CG30174; Dmel_CG30179; Dmel_CG33149
    Summary
    Involved in muscle tissue development. Located in Z disc and nucleus. Colocalizes with actin cytoskeleton. Is expressed in several structures, including adult head; adult heart; larval muscle cell; larval muscle system; and somatic mesoderm. Orthologous to human CSRP1 (cysteine and glycine rich protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mlp60A in Genome Data Viewer
    Location:
    60B8-60B8; 2-106 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24074602..24078223)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19962125..19965746)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene yorkie Neighboring gene Glycerol-3-phosphate acyltransferase 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two muscle-specific LIM proteins in Drosophila. Stronach BE, et al. J Cell Biol, 1996 Sep. PMID 8794860, Free PMC Article
    2. Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation. Arber S, et al. Cell, 1994 Oct 21. PMID 7954791
    3. Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ. Arber S, et al. Genes Dev, 1996 Feb 1. PMID 8595880
    4. The CRP/MLP/TLP family of LIM domain proteins: acting by connecting. Weiskirchen R, et al. Bioessays, 2003 Feb. PMID 12539241
    5. The Neuronal Overexpression of Gclc in Drosophila melanogaster Induces Life Extension With Longevity-Associated Transcriptomic Changes in the Thorax. Moskalev A, et al. Front Genet, 2019. PMID 30891062, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in muscle tissue development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc HDA PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    muscle LIM protein at 60A
    Names
    CG42309-PB
    CG42309-PC
    CG42309-PE
    CG42309-PF
    Mlp60A-PB
    Mlp60A-PC
    Mlp60A-PE
    Mlp60A-PF
    Muscle-specific LIM protein at 60A
    muscle LIM protein 60A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24074602..24078223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299892.1 → NP_001286821.1  muscle LIM protein at 60A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZP9
      Conserved Domains (3) summary
      cd09326
      Location:108 → 161
      LIM_CRP_like; The LIM domains of Cysteine Rich Protein (CRP) family
      cd09404
      Location:10 → 63
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
      cl02475
      Location:316 → 369
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_001144278.3 → NP_001137750.1  muscle LIM protein at 60A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZP9
      Conserved Domains (3) summary
      cd09326
      Location:108 → 161
      LIM_CRP_like; The LIM domains of Cysteine Rich Protein (CRP) family
      cd09404
      Location:10 → 63
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
      cl02475
      Location:316 → 369
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. NM_176255.3 → NP_788435.1  muscle LIM protein at 60A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788435.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53777, Q1RKS4, Q9W1B4
      UniProtKB/TrEMBL
      A0A0B4LGF8
      Related
      FBpp0288974
      Conserved Domains (1) summary
      cd09404
      Location:10 → 63
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A

    4. NM_001299891.1 → NP_001286820.1  muscle LIM protein at 60A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286820.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53777, Q1RKS4, Q9W1B4
      UniProtKB/TrEMBL
      A0A0B4LGF8
      Conserved Domains (1) summary
      cd09404
      Location:10 → 63
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGF8 A0A0B4LGF8
    B7YZP9 B7YZP9
    P53777.1 P53777

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