Car5b carbonic anhydrase 5b, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Car5bprovided by MGI
Official Full Name: carbonic anhydrase 5b, mitochondrialprovided by MGI
Primary source: MGI:MGI:1926249
See related: Ensembl:ENSMUSG00000031373 AllianceGenome:MGI:1926249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAVB; Ca5b; CarVb; 7330410H16Rik; D730005F19Rik
Summary: Enables carbonate dehydratase activity. Acts upstream of or within response to bacterium. Located in mitochondrion. Is expressed in brain; inner ear; liver; metanephros; and trunk. Orthologous to human CA5B (carbonic anhydrase 5B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 31.5), genital fat pad adult (RPKM 23.6) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F5; X 76.03 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (162759818..162811006, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (163976822..164028010, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease.
Title: Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease.
both Car5A and Car5B contribute to both ammonia detoxification (ureagenesis) and regulation of fasting blood sugar (gluconeogenesis).
Title: Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism.
Car5b and Car13 showed the highest signals in the mouse harderian gland.
Title: Carbonic anhydrases in the mouse harderian gland.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Spontaneous (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Car5b (e-PCR), detects polymorphism
- UniSTS:506775

D5Mit392.1 (e-PCR), detects polymorphism
- UniSTS:130544

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables carbonate dehydratase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carbonic anhydrase 5B, mitochondrial

Names: CA-VB; carbonate dehydratase VB; carbonic anhydrase VB

NP_851832.2

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181315.4 → NP_851832.2 carbonic anhydrase 5B, mitochondrial precursor

See identical proteins and their annotated locations for NP_851832.2

Status: VALIDATED

Source sequence(s)

AK085670, BX469932, BY121187, CD802657

Consensus CDS

CCDS30515.1

UniProtKB/Swiss-Prot

Q8C3J9, Q8K014, Q9QZA0

Related

ENSMUSP00000033739.5, ENSMUST00000033739.5

Conserved Domains (1) summary

cl00012
Location:61 → 296

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...