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    ITSN1 intersectin 1 [ Bufo gargarizans (Asiatic toad) ]

    Gene ID: 122930818, updated on 22-Mar-2024

    Summary

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    Gene symbol
    ITSN1
    Gene description
    intersectin 1
    See related
    EnsemblRapid:ENSBGGG00000008473
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bufo gargarizans
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Bufo
    Orthologs
    human mouse all
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    Genomic context

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    See ITSN1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    100 current ASM1485885v1 (GCF_014858855.1) 3 NC_058082.1 (596599087..596731916)

    Chromosome 3 - NC_058082.1Genomic Context describing neighboring genes Neighboring gene NACHT, LRR and PYD domains-containing protein 3-like Neighboring gene crystallin zeta like 1 Neighboring gene uncharacterized LOC122930819 Neighboring gene ATP synthase peripheral stalk subunit OSCP Neighboring gene small integral membrane protein 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_058082.1 Chromosome 3 Reference ASM1485885v1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in endosomal transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intracellular vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    intersectin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Bufo gargarizans Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM1485885v1 Primary Assembly

    Genomic

    1. NC_058082.1 Reference ASM1485885v1 Primary Assembly

      Range
      596599087..596731916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_044284451.1 → XP_044140386.1  intersectin-1 isoform X1

      Related
      ENSBGGP00000011197.1, ENSBGGT00000012618.1
      Conserved Domains (11) summary
      PTZ00266
      Location:354 → 412
      PTZ00266; NIMA-related protein kinase; Provisional
      cd08375
      Location:1572 → 1706
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:215 → 310
      EH; Eps15 homology domain
      cd11987
      Location:743 → 797
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11991
      Location:996 → 1047
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1064 → 1128
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1148 → 1201
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00160
      Location:1228 → 1411
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1438 → 1569
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      TIGR02169
      Location:393 → 707
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl17036
      Location:907 → 958
      SH3; Src Homology 3 domain superfamily

    2. XM_044284452.1 → XP_044140387.1  intersectin-1 isoform X2

      Conserved Domains (11) summary
      PTZ00266
      Location:354 → 412
      PTZ00266; NIMA-related protein kinase; Provisional
      cd08375
      Location:1570 → 1704
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:215 → 310
      EH; Eps15 homology domain
      cd11987
      Location:741 → 795
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11991
      Location:994 → 1045
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1062 → 1126
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1146 → 1199
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00160
      Location:1226 → 1409
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1436 → 1567
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      TIGR02169
      Location:393 → 707
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl17036
      Location:905 → 956
      SH3; Src Homology 3 domain superfamily

    3. XM_044284453.1 → XP_044140388.1  intersectin-1 isoform X3

      Related
      ENSBGGP00000011225.1, ENSBGGT00000012646.1
      Conserved Domains (11) summary
      PTZ00266
      Location:294 → 352
      PTZ00266; NIMA-related protein kinase; Provisional
      cd08375
      Location:1512 → 1646
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:155 → 250
      EH; Eps15 homology domain
      cd11987
      Location:683 → 737
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11991
      Location:936 → 987
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1004 → 1068
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1088 → 1141
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00160
      Location:1168 → 1351
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13264
      Location:1378 → 1509
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      TIGR02169
      Location:333 → 647
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl17036
      Location:847 → 898
      SH3; Src Homology 3 domain superfamily

    4. XM_044284454.1 → XP_044140389.1  intersectin-1 isoform X4

      Conserved Domains (8) summary
      PTZ00266
      Location:354 → 412
      PTZ00266; NIMA-related protein kinase; Provisional
      smart00027
      Location:215 → 310
      EH; Eps15 homology domain
      cd11987
      Location:743 → 797
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11991
      Location:996 → 1047
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1064 → 1128
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1148 → 1201
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      TIGR02169
      Location:393 → 707
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl17036
      Location:907 → 958
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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