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    DROSHA drosha ribonuclease III [ Gallus gallus (chicken) ]

    Gene ID: 420911, updated on 3-Dec-2024

    Summary

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    Symbol
    DROSHAprovided by CGNC
    Full Name
    drosha ribonuclease IIIprovided by CGNC
    Primary source
    CGNC:9781
    See related
    Ensembl:ENSGALG00010011033
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    RNASEN
    Orthologs
    human mouse all
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    Genomic context

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    See DROSHA in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (68901985..68974035)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (68886789..68958332)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121113081 Neighboring gene melanocortin 4 receptor Neighboring gene C5orf22 Neighboring gene cadherin 6 Neighboring gene uncharacterized LOC124417730

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ribonuclease III activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pre-miRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in primary miRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonuclease 3
    Names
    drosha, ribonuclease type III
    ribonuclease III, nuclear
    ribonuclease type III, nuclear
    NP_001006379.2
    NP_001383288.1
    NP_001383289.1
    NP_001383290.1
    NP_001383291.1
    NP_001383292.1
    XP_046780377.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006379.3 → NP_001006379.2  ribonuclease 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000040
      UniProtKB/TrEMBL
      A0A8V0YGC5, Q5ZIR3
      Conserved Domains (3) summary
      PRK00102
      Location:1067 → 1295
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:919 → 1033
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      TIGR01642
      Location:208 → 312
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    2. NM_001396359.1 → NP_001383288.1  ribonuclease 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000040
      UniProtKB/TrEMBL
      A0A8V0YGC5, Q5ZIR3
      Conserved Domains (3) summary
      PRK00102
      Location:1067 → 1295
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:919 → 1033
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      TIGR01642
      Location:208 → 312
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    3. NM_001396360.1 → NP_001383289.1  ribonuclease 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000040
      UniProtKB/TrEMBL
      A0A8V0YGC5, Q5ZIR3
      Conserved Domains (3) summary
      PRK00102
      Location:1067 → 1295
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:919 → 1033
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      TIGR01642
      Location:208 → 312
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    4. NM_001396361.1 → NP_001383290.1  ribonuclease 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000040
      UniProtKB/TrEMBL
      A0A8V0YGC5, Q5ZIR3
      Related
      ENSGALP00010015050.1, ENSGALT00010026441.1
      Conserved Domains (3) summary
      PRK00102
      Location:1067 → 1295
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:919 → 1033
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      TIGR01642
      Location:208 → 312
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    5. NM_001396362.1 → NP_001383291.1  ribonuclease 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000040
      UniProtKB/TrEMBL
      A0A8V0YGC5, Q5ZIR3
      Conserved Domains (3) summary
      PRK00102
      Location:1067 → 1295
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:919 → 1033
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      TIGR01642
      Location:208 → 312
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    6. NM_001396363.1 → NP_001383292.1  ribonuclease 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000040
      UniProtKB/TrEMBL
      A0A8V0YGC5, Q5ZIR3
      Conserved Domains (3) summary
      PRK00102
      Location:1067 → 1295
      rnc; ribonuclease III; Reviewed
      cd00593
      Location:919 → 1033
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      TIGR01642
      Location:208 → 312
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      68901985..68974035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046924421.1 → XP_046780377.1  ribonuclease 3 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YGC5, Q5ZIR3

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      68886789..68958332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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