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    nca-2 Ion transport domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175674, updated on 4-Jan-2025

    Summary

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    Official Symbol
    nca-2
    Official Full Name
    Ion transport domain-containing protein
    Primary source
    WormBase:WBGene00003558
    Locus tag
    CELE_C27F2.2
    See related
    AllianceGenome:WB:WBGene00003558
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable monoatomic cation channel activity. Involved in positive regulation of GABAergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and positive regulation of locomotion. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including intestine and nervous system. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Orthologous to human NALCN (sodium leak channel, non-selective). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See nca-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    23
    Sequence:
    Chromosome: III; NC_003281.10 (4965571..4979738)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene JmjC domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Potassium channel domain-containing protein Neighboring gene putative F-box protein C27F2.7 Neighboring gene PCI domain-containing protein 2 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Corrigendum. . Genetics, 2017 Aug. PMID 28778879, Free PMC Article
    2. De novo missense mutations in NALCN cause developmental and intellectual impairment with hypotonia. Fukai R, et al. J Hum Genet, 2016 May. PMID 26763878
    3. Dopamine negatively modulates the NCA ion channels in C. elegans. Topalidou I, et al. PLoS Genet, 2017 Oct. PMID 28968387, Free PMC Article
    4. The NCA-1 and NCA-2 Ion Channels Function Downstream of G(q) and Rho To Regulate Locomotion in Caenorhabditis elegans. Topalidou I, et al. Genetics, 2017 May. PMID 28325749, Free PMC Article
    5. The transcription factor unc-130/FOXD3/4 contributes to the biphasic calcium response required to optimize avoidance behavior. Hori S, et al. Sci Rep, 2022 Feb 3. PMID 35115609, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic epistasis experiments suggest that GRK-2 acts on the D2-like dopamine receptor DOP-3 to inhibit Go signaling and positively modulate NCA-1 and NCA-2 activity.
      Title: Dopamine negatively modulates the NCA ion channels in C. elegans.
    2. Our results suggest that NCA-1 and NCA-2 are physiologically relevant targets of neuronal Gq-Rho signaling in C. elegans
      Title: The NCA-1 and NCA-2 Ion Channels Function Downstream of G(q) and Rho To Regulate Locomotion in Caenorhabditis elegans.
    3. UNC-80 is required for the proper localization of the NCA-1 and NCA-2 ion channel subunits.
      Title: UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of synaptic transmission, GABAergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of synaptic transmission, cholinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic transmission, cholinergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ion transport domain-containing protein
    NP_001129835.1
    • Confirmed by transcript evidence
    NP_498054.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4965571..4979738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065653.6 → NP_498054.2  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498054.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDM1
      Conserved Domains (1) summary
      pfam00520
      Location:1288 → 1518
      Ion_trans; Ion transport protein

    2. NM_001136363.4 → NP_001129835.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129835.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG32
      Conserved Domains (1) summary
      pfam00520
      Location:1266 → 1496
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version

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