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    MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [ Gallus gallus (chicken) ]

    Gene ID: 423508, updated on 17-Aug-2024

    Summary

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    Symbol
    MTHFD1provided by CGNC
    Full Name
    methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1provided by CGNC
    Primary source
    CGNC:8944
    See related
    Ensembl:ENSGALG00010017583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See MTHFD1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (52431500..52473180, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (52410219..52451836, complement)

    Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 36 Neighboring gene uncharacterized LOC124418019 Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC124418020 Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene A-kinase anchoring protein 5 Neighboring gene estrogen receptor 2 Neighboring gene uncharacterized LOC121110835 Neighboring gene spectrin repeat containing nuclear envelope protein 2 Neighboring gene transfer RNA leucine (anticodon CAG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables formate-tetrahydrofolate ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methenyltetrahydrofolate cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-1-tetrahydrofolate synthase, cytoplasmic
    Names
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
    NP_001034392.2
    NP_001384156.1
    NP_001384157.1
    NP_001384158.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039303.2 → NP_001034392.2  C-1-tetrahydrofolate synthase, cytoplasmic isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q5ZI76
      Related
      ENSGALP00010025011.1, ENSGALT00010042521.1
      Conserved Domains (2) summary
      PLN02759
      Location:310 → 935
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    2. NM_001397227.1 → NP_001384156.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q5ZI76
      Conserved Domains (2) summary
      PLN02759
      Location:310 → 937
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    3. NM_001397228.1 → NP_001384157.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q5ZI76
      Conserved Domains (2) summary
      PLN02759
      Location:310 → 935
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    4. NM_001397229.1 → NP_001384158.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q5ZI76
      Conserved Domains (2) summary
      PLN02759
      Location:310 → 935
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      52431500..52473180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      52410219..52451836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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