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    Exd2 Exonuclease 3'-5' domain-containing 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41374, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Exd2provided by FlyBase
    Official Full Name
    Exonuclease 3'-5' domain-containing 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037901
    Locus tag
    Dmel_CG6744
    See related
    AllianceGenome:FB:FBgn0037901
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6744; dEXD2; Dmel\CG6744; EXD2
    Summary
    Enables 3'-5'-RNA exonuclease activity. Involved in positive regulation of mitochondrial translation and somatic cell DNA recombination. Located in mitochondrion. Is expressed in organism. Used to study Werner syndrome. Orthologous to human EXD2 (exonuclease 3'-5' domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Exd2 in Genome Data Viewer
    Location:
    86E5-86E5; 3-51 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11433488..11435703, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7259210..7261425, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Spastizin Neighboring gene Ribosomal protein L24-like Neighboring gene uncharacterized protein Neighboring gene D-aminoacyl-tRNA deacylase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sarcomere length short Neighboring gene mir-4945 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation. Silva J, et al. Nat Cell Biol, 2018 Feb. PMID 29335528
    2. Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease. Cox LS, et al. Ann N Y Acad Sci, 2007 Nov. PMID 18056975
    3. Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases. Lautrup S, et al. Biogerontology, 2019 Jun. PMID 30666569
    4. Discovery of insect and human dengue virus host factors. Sessions OM, et al. Nature, 2009 Apr 23. PMID 19396146, Free PMC Article
    5. The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria. Ge DT, et al. Mol Cell, 2019 Jun 6. PMID 31076285, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3'-5' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables 3'-5'-RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in somatic cell DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    exonuclease 3'-5' domain-containing 2
    Names
    CG6744-PA
    CG6744-PB
    Exd2-PA
    Exd2-PB
    NP_001247048.1
    NP_650075.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11433488..11435703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141818.2 → NP_650075.1  exonuclease 3'-5' domain-containing 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650075.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGN7
      Related
      FBpp0081878, FBtr0082402
      Conserved Domains (2) summary
      cd06141
      Location:62 → 226
      WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
      cl21519
      Location:363 → 432
      Cas8a1_I-A; CRISPR/Cas system-associated protein Cas8a1

    2. NM_001260119.2 → NP_001247048.1  exonuclease 3'-5' domain-containing 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGN7
      Conserved Domains (2) summary
      cd06141
      Location:62 → 226
      WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
      cl21519
      Location:363 → 432
      Cas8a1_I-A; CRISPR/Cas system-associated protein Cas8a1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGN7.2 Q9VGN7

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