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    MED4 Mediator complex subunit 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38799, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MED4provided by FlyBase
    Official Full Name
    Mediator complex subunit 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0035754
    Locus tag
    Dmel_CG8609
    See related
    AllianceGenome:FB:FBgn0035754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8609; Dmel\CG8609; dp34; dTRAP36; med4; Med4; Med4/TRAP36; p34; Trap36
    Summary
    Enables transcription coregulator activity. Contributes to transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II. Located in nucleus. Part of mediator complex. Is expressed in central brain primordium; embryonic brain; organism; and ventral nerve cord primordium. Orthologous to human MED4 (mediator complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MED4 in Genome Data Viewer
    Location:
    65E9-65E9; 3-19 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7249529..7250527, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7242629..7243627, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene meiotic P22 Neighboring gene antisense RNA:CR43470 Neighboring gene Cell division cycle 27 Neighboring gene uncharacterized protein Neighboring gene unc-13-4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth. Guo L, et al. Nucleic Acids Res, 2016 Sep 19. PMID 27207882, Free PMC Article
    2. Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Boube M, et al. Cell, 2002 Jul 26. PMID 12150923
    3. Large-scale analysis of Drosophila core promoter function using synthetic promoters. Qi Z, et al. Mol Syst Biol, 2022 Feb. PMID 35156763, Free PMC Article
    4. Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myogenic and neuromuscular developmental pathways. Montgomery SL, et al. PLoS One, 2014. PMID 25360876, Free PMC Article
    5. Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Park JM, et al. Mol Cell, 2001 Jul. PMID 11511356

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coregulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mediator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit 4
    Names
    CG8609-PA
    MED4-PA
    mediator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7249529..7250527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139837.3 → NP_648094.1  mediator complex subunit 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VS38
      Related
      FBpp0076599
      Conserved Domains (1) summary
      pfam10018
      Location:47 → 189
      Med4; Vitamin-D-receptor interacting Mediator subunit 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS38.1 Q9VS38

    Gene LinkOut

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