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    Pgant8 Polypeptide N-Acetylgalactosaminyltransferase 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgant8provided by FlyBase
    Official Full Name
    Polypeptide N-Acetylgalactosaminyltransferase 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0036529
    Locus tag
    Dmel_CG7297
    See related
    AllianceGenome:FB:FBgn0036529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7297; Dmel\CG7297; pgant8
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in oligosaccharide biosynthetic process. Predicted to be active in Golgi apparatus. Is expressed in several structures, including adult head; embryonic/larval hindgut; embryonic/larval midgut primordium; foregut primordium; and hindgut proper primordium. Orthologous to human GALNTL6 (polypeptide N-acetylgalactosaminyltransferase like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgant8 in Genome Data Viewer
    Location:
    71F1-71F1; 3-43 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15683872..15686598)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15676972..15679698)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene comm2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development. Tian E, et al. Glycobiology, 2006 Feb. PMID 16251381
    2. Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster. Ten Hagen KG, et al. J Biol Chem, 2003 Sep 12. PMID 12829714
    3. Multiple members of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family are essential for viability in Drosophila. Tran DT, et al. J Biol Chem, 2012 Feb 17. PMID 22157008, Free PMC Article
    4. Dissecting the biological role of mucin-type O-glycosylation using RNA interference in Drosophila cell culture. Zhang L, et al. J Biol Chem, 2010 Nov 5. PMID 20807760, Free PMC Article
    5. An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand. Zhang L, et al. J Biol Chem, 2010 Jun 18. PMID 20371600, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polypeptide N-acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polypeptide N-Acetylgalactosaminyltransferase 8
    Names
    CG7297-PA
    Pgant8-PA
    polypeptide GalNAc transferase 8
    NP_648800.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15683872..15686598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140543.4 → NP_648800.1  polypeptide N-Acetylgalactosaminyltransferase 8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648800.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUT6
      Related
      FBpp0075331
      Conserved Domains (4) summary
      cd02510
      Location:131 → 430
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG1216
      Location:128 → 427
      GT2; Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism]
      cd00161
      Location:448 → 572
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:446 → 570
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUT6.1 Q9VUT6

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