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    Epo erythropoietin [ Mus musculus (house mouse) ]

    Gene ID: 13856, updated on 9-Dec-2024

    Summary

    Official Symbol
    Epoprovided by MGI
    Official Full Name
    erythropoietinprovided by MGI
    Primary source
    MGI:MGI:95407
    See related
    Ensembl:ENSMUSG00000029711 AllianceGenome:MGI:95407
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes the glycoprotein hormone erythropoietin that regulates the production of red blood cells and biosynthesis of hemoglobin. The predominant expression of this gene shifts from the liver during fetal development to kidney in adults. A complete lack of the encoded protein causes embryonic lethal anemia in mice. The conditional inactivation of this gene in adult mice results in a chronic, normocytic and normochromic anemia. Transgenic mice expressing the human ortholog of this gene exhibit polycythemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Epo in Genome Data Viewer
    Location:
    5 G2; 5 76.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137481282..137484078, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137483020..137485816, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zonadhesin Neighboring gene ribosomal protein L36, pseudogene 9 Neighboring gene predicted gene, 38725 Neighboring gene predicted gene, 36056 Neighboring gene RIKEN cDNA 9130604C24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137943213-137943434 Neighboring gene processing of precursor 7, ribonuclease P family, (S. cerevisiae)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity  
    enables cytokine activity  
    enables erythropoietin receptor binding  
    enables erythropoietin receptor binding  
    enables erythropoietin receptor binding  
    enables erythropoietin receptor binding PubMed 
    enables hormone activity  
    enables protein kinase activator activity  
    enables protein kinase activator activity PubMed 
    Items 1 - 25 of 61
    Process Evidence Code Pubs
    involved_in acute-phase response  
    involved_in angiogenesis PubMed 
    acts_upstream_of_or_within apoptotic process PubMed 
    involved_in cardiac muscle tissue morphogenesis PubMed 
    involved_in cell surface receptor signaling pathway via STAT  
    involved_in cellular hyperosmotic response  
    involved_in cellular hyperosmotic response  
    acts_upstream_of_or_within embryo implantation PubMed 
    acts_upstream_of_or_within erythrocyte differentiation PubMed 
    involved_in erythrocyte differentiation  
    involved_in erythrocyte maturation  
    involved_in erythropoietin-mediated signaling pathway  
    involved_in erythropoietin-mediated signaling pathway  
    involved_in erythropoietin-mediated signaling pathway  
    involved_in heart morphogenesis PubMed 
    acts_upstream_of_or_within hemoglobin biosynthetic process PubMed 
    acts_upstream_of myeloid cell apoptotic process PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of calcium ion transport into cytosol  
    involved_in negative regulation of calcium ion transport into cytosol  
    involved_in negative regulation of cation channel activity  
    involved_in negative regulation of erythrocyte apoptotic process  
    involved_in negative regulation of erythrocyte apoptotic process  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  
    acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in peptidyl-serine phosphorylation PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of Ras protein signal transduction  
    involved_in positive regulation of Ras protein signal transduction  
    involved_in positive regulation of Ras protein signal transduction  
    involved_in positive regulation of activated T cell proliferation  
    involved_in positive regulation of activated T cell proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of protein kinase activity PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
    involved_in response to axon injury  
    involved_in response to dexamethasone  
    involved_in response to electrical stimulus  
    involved_in response to estrogen  
    involved_in response to hyperoxia  
    acts_upstream_of_or_within response to hypoxia PubMed 
    involved_in response to interleukin-1  
    involved_in response to lipopolysaccharide  
    involved_in response to salt stress  
    involved_in response to testosterone  
    involved_in response to vitamin A  
    involved_in vasculogenesis involved in coronary vascular morphogenesis PubMed 
    involved_in ventricular cardiac muscle tissue morphogenesis PubMed 
    involved_in visceral serous pericardium development PubMed 
    Items 1 - 25 of 61
    Component Evidence Code Pubs
    located_in cell body  
    located_in cell body  
    located_in cell surface  
    located_in cell surface  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312875.1NP_001299804.1  erythropoietin isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      BC119265
      Consensus CDS
      CCDS84978.1
      UniProtKB/TrEMBL
      B7ZMY9
      Related
      ENSMUSP00000106668.2, ENSMUST00000111039.3
      Conserved Domains (1) summary
      pfam00758
      Location:30190
      EPO_TPO; Erythropoietin/thrombopoietin
    2. NM_007942.2NP_031968.1  erythropoietin isoform 1 precursor

      See identical proteins and their annotated locations for NP_031968.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      BC119265
      Consensus CDS
      CCDS39332.1
      UniProtKB/Swiss-Prot
      P07321
      UniProtKB/TrEMBL
      Q0VED9
      Related
      ENSMUSP00000031723.7, ENSMUST00000031723.14
      Conserved Domains (1) summary
      pfam00758
      Location:30191
      EPO_TPO; Erythropoietin/thrombopoietin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137481282..137484078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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