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    Ccdc92 coiled-coil domain containing 92 [ Mus musculus (house mouse) ]

    Gene ID: 215707, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ccdc92provided by MGI
    Official Full Name
    coiled-coil domain containing 92provided by MGI
    Primary source
    MGI:MGI:106485
    See related
    Ensembl:ENSMUSG00000037979 AllianceGenome:MGI:106485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D5Bwg0834e
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in innate immune response. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in centriole. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and sensory organ. Orthologous to human CCDC92 (coiled-coil domain containing 92). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 212.4), cerebellum adult (RPKM 45.1) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc92 in Genome Data Viewer
    Location:
    5 G1.1; 5 63.85 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124911482..124939261, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124834432..124862499, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:125079413-125079714 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit A2 Neighboring gene dynein, axonemal, heavy chain 10 Neighboring gene zinc finger protein 664 Neighboring gene predicted gene, 32449

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CCDC92 deficiency ameliorates podocyte lipotoxicity in diabetic kidney disease. Zuo F, et al. Metabolism, 2024 Jan. PMID 37952690
    2. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice. Ren L, et al. iScience, 2023 Jan 20. PMID 36594018, Free PMC Article
    3. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
    4. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    5. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38387

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 92

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418046.1 → NP_001404975.1  coiled-coil domain-containing protein 92

      Status: VALIDATED

      Source sequence(s)
      AC164649
      UniProtKB/Swiss-Prot
      Q8VDN4

    2. NM_144819.3 → NP_659068.1  coiled-coil domain-containing protein 92

      See identical proteins and their annotated locations for NP_659068.1

      Status: VALIDATED

      Source sequence(s)
      AC164649
      Consensus CDS
      CCDS19681.1
      UniProtKB/Swiss-Prot
      Q8VDN4
      Related
      ENSMUSP00000038075.8, ENSMUST00000036206.14
      Conserved Domains (2) summary
      TIGR04523
      Location:5 → 151
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14916
      Location:7 → 63
      CCDC92; Coiled-coil domain of unknown function

    RNA

    1. NR_184680.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164649

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124911482..124939261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320799.1 → XP_017176288.1  coiled-coil domain-containing protein 92 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDN4.1 GenPept UniProtKB/Swiss-Prot:Q8VDN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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