Pcyox1 prenylcysteine oxidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pcyox1provided by RGD
Official Full Name: prenylcysteine oxidase 1provided by RGD
Primary source: RGD:628652
See related: EnsemblRapid:ENSRNOG00000016704 AllianceGenome:RGD:628652
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Clp55
Summary: Predicted to enable FAD binding activity and prenylcysteine oxidase activity. Involved in chloride transmembrane transport. Predicted to be located in lysosome. Predicted to be part of very-low-density lipoprotein particle. Orthologous to human PCYOX1 (prenylcysteine oxidase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 405.8), Brain (RPKM 329.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (120389545..120400382, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (118832114..118842951, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (118187133..118198029, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables farnesylcysteine lyase activity	IEA Inferred from Electronic Annotation more info
enables prenylcysteine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prenylcysteine oxidase activity	IEA Inferred from Electronic Annotation more info
enables prenylcysteine oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prenylated protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prenylated protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in prenylated protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in prenylcysteine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prenylcysteine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in prenylcysteine catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prenylcysteine oxidase 1

Names: chloride ion pump-associated 55 kDa protein

NP_659553.1

EC 1.8.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145085.2 → NP_659553.1 prenylcysteine oxidase 1 precursor

See identical proteins and their annotated locations for NP_659553.1

Status: PROVISIONAL

Source sequence(s)

BC078719

UniProtKB/Swiss-Prot

Q99ML5

UniProtKB/TrEMBL

A0A8L2QBX2, A6IAW5

Related

ENSRNOP00000022532.5, ENSRNOT00000022532.8

Conserved Domains (2) summary

pfam07156
Location:130 → 493

Prenylcys_lyase; Prenylcysteine lyase

pfam13450
Location:39 → 106

NAD_binding_8; NAD(P)-binding Rossmann-like domain