Defb19 defensin beta 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Defb19provided by MGI
Official Full Name: defensin beta 19provided by MGI
Primary source: MGI:MGI:2385955
See related: Ensembl:ENSMUSG00000050645 AllianceGenome:MGI:2385955
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tdl; BD-19; Defb24; mBD-19
Summary: Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in antifungal innate immune response; defense response to Gram-negative bacterium; and defense response to Gram-positive bacterium. Predicted to be located in extracellular region. Is expressed in metanephros and reproductive system. Used to study female reproductive system disease. Orthologous to human DEFB119 (defensin beta 119). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 198.2) See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 75.31 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (152418006..152422232, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (152576086..152580312, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility.
Title: β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility.
Tdl is specifically expressed in Sertoli cell-lineage in seminiferous cords in embryonic testes, but not in embryonic ovaries after 12.5dpc when the sexual differentiation of gonads is initiated.
Title: Testis-specific expression of a novel mouse defensin-like gene, Tdl.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

Defb19 (e-PCR), detects polymorphism
- UniSTS:464665

Tdl-pending (e-PCR), detects polymorphism
- UniSTS:257007

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antifungal innate immune response	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-defensin 19

Names: beta-defensin 24; testis-specific beta-defensin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.