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    UBA3 ubiquitin like modifier activating enzyme 3 [ Macaca fascicularis (crab-eating macaque) ]

    Gene ID: 102116964, updated on 3-Dec-2024

    Summary

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    Gene symbol
    UBA3
    Gene description
    ubiquitin like modifier activating enzyme 3
    See related
    Ensembl:ENSMFAG00000036648
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca fascicularis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See UBA3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 2 NC_088376.1 (132145789..132171250, complement)
    102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 2 NC_052256.1 (70877491..70902941)

    Chromosome 2 - NC_088376.1Genomic Context describing neighboring genes Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene TATA element modulatory factor 1 Neighboring gene ARF like GTPase 6 interacting protein 5 Neighboring gene leiomodin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rate of evolution in brain-expressed genes in humans and other primates. Wang HY, et al. PLoS Biol, 2007 Feb. PMID 17194215, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NEDD8 activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein neddylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NEDD8-activating enzyme E1 catalytic subunit
    XP_005547636.1
    XP_015300825.1
    XP_015300826.1
    XP_045241826.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference T2T-MFA8v1.0

    Genomic

    1. NC_088376.1 Reference T2T-MFA8v1.0

      Range
      132145789..132171250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015445340.3 → XP_015300826.1  NEDD8-activating enzyme E1 catalytic subunit isoform X4

      UniProtKB/TrEMBL
      A0A2K5WLF3, G7NZ92
      Related
      ENSMFAP00000038002.1
      Conserved Domains (2) summary
      cd01488
      Location:48 → 327
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam08825
      Location:335 → 420
      E2_bind; E2 binding domain

    2. XM_005547579.4 → XP_005547636.1  NEDD8-activating enzyme E1 catalytic subunit isoform X2

      See identical proteins and their annotated locations for XP_005547636.1

      UniProtKB/TrEMBL
      A0A2K5WLL1, G7NZ92
      Related
      ENSMFAP00000038010.1
      Conserved Domains (2) summary
      cd01488
      Location:57 → 354
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam08825
      Location:362 → 447
      E2_bind; E2 binding domain

    3. XM_015445339.3 → XP_015300825.1  NEDD8-activating enzyme E1 catalytic subunit isoform X3

      UniProtKB/TrEMBL
      G7NZ92
      Conserved Domains (2) summary
      cd01488
      Location:62 → 341
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam08825
      Location:349 → 434
      E2_bind; E2 binding domain

    4. XM_045385891.2 → XP_045241826.1  NEDD8-activating enzyme E1 catalytic subunit isoform X1

      UniProtKB/TrEMBL
      G7NZ92, I7GJ84
      Conserved Domains (2) summary
      cd01488
      Location:71 → 368
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam08825
      Location:376 → 461
      E2_bind; E2 binding domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001287323.1: Suppressed sequence

      Description
      NM_001287323.1: This RefSeq record was removed as a result of standard genome annotation processing. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version

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