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    CG15097 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37172, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG15097provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034396
    Locus tag
    Dmel_CG15097
    See related
    AllianceGenome:FB:FBgn0034396
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dm.CG15097; Dmel\CG15097
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in Bolwig organ; embryonic head sensory system; embryonic large intestine; ganglia; and sensory nervous system primordium. Orthologous to human KLHL17 (kelch like family member 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG15097 in Genome Data Viewer
    Location:
    55F6-55F6; 2-86 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18822188..18829699, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14709693..14717204, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43418 Neighboring gene long non-coding RNA:CR46234 Neighboring gene Prohibitin 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The BACK domain in BTB-kelch proteins. Stogios PJ, et al. Trends Biochem Sci, 2004 Dec. PMID 15544948
    2. Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. Kim LK, et al. PLoS Biol, 2007 Sep. PMID 17803358, Free PMC Article
    3. Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. Cao C, et al. J Cell Biol, 2007 Mar 12. PMID 17339378, Free PMC Article
    4. Identification and investigation of Drosophila postsynaptic density homologs. Liebl FL, et al. Bioinform Biol Insights, 2008 Nov 3. PMID 19812789, Free PMC Article
    5. Flying through the drosophila cytoskeletal genome. Goldstein LS, et al. J Cell Biol, 2000 Jul 24. PMID 10908588, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG15097-PA
    CG15097-PC
    CG15097-PD
    CG15097-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18822188..18829699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202044.2 → NP_001188973.1  uncharacterized protein Dmel_CG15097, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD92
      Conserved Domains (6) summary
      smart00612
      Location:417 → 463
      Kelch; Kelch domain
      PHA03098
      Location:65 → 539
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:359 → 402
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:63 → 166
      BTB; BTB/POZ domain
      pfam01344
      Location:499 → 543
      Kelch_1; Kelch motif
      pfam07707
      Location:174 → 276
      BACK; BTB And C-terminal Kelch

    2. NM_176232.3 → NP_788412.2  uncharacterized protein Dmel_CG15097, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788412.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBE3
      Conserved Domains (6) summary
      smart00612
      Location:417 → 463
      Kelch; Kelch domain
      PHA03098
      Location:65 → 539
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:359 → 402
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:63 → 166
      BTB; BTB/POZ domain
      pfam01344
      Location:499 → 543
      Kelch_1; Kelch motif
      pfam07707
      Location:174 → 276
      BACK; BTB And C-terminal Kelch

    3. NM_001274150.1 → NP_001261079.1  uncharacterized protein Dmel_CG15097, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261079.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEU3
      Conserved Domains (6) summary
      smart00612
      Location:417 → 463
      Kelch; Kelch domain
      PHA03098
      Location:65 → 539
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:359 → 402
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:63 → 166
      BTB; BTB/POZ domain
      pfam01344
      Location:499 → 543
      Kelch_1; Kelch motif
      pfam07707
      Location:174 → 276
      BACK; BTB And C-terminal Kelch

    4. NM_137533.4 → NP_611377.1  uncharacterized protein Dmel_CG15097, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2Q6
      Related
      FBpp0085812
      Conserved Domains (5) summary
      smart00612
      Location:313 → 359
      Kelch; Kelch domain
      sd00038
      Location:255 → 298
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:9 → 62
      BTB; BTB/POZ domain
      pfam01344
      Location:395 → 439
      Kelch_1; Kelch motif
      pfam07707
      Location:70 → 172
      BACK; BTB And C-terminal Kelch
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD92 A0A0B4JD92
    A0A0B4KEU3 A0A0B4KEU3
    A1ZBE3 A1ZBE3
    Q7K2Q6 Q7K2Q6
    Q8IH99 Q8IH99

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