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    Ap3s1 adaptor related protein complex 3 subunit sigma 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302290, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ap3s1provided by RGD
    Official Full Name
    adaptor related protein complex 3 subunit sigma 1provided by RGD
    Primary source
    RGD:1311115
    See related
    EnsemblRapid:ENSRNOG00000003829 AllianceGenome:RGD:1311115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in anterograde synaptic vesicle transport and vesicle-mediated transport. Is active in synaptic vesicle. Orthologous to human AP3S1 (adaptor related protein complex 3 subunit sigma 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 101.8), Thymus (RPKM 74.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap3s1 in Genome Data Viewer
    Location:
    18q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (41649321..41718221)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (39462728..39531622)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (40732472..40798064)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S23-like Neighboring gene cysteine dioxygenase type 1 Neighboring gene uncharacterized LOC134482941 Neighboring gene autophagy related 12 Neighboring gene uncharacterized LOC120098117 Neighboring gene protein SET-like Neighboring gene laeverin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. AP-3: an adaptor-like protein complex with ubiquitous expression. Dell'Angelica EC, et al. EMBO J, 1997 Mar 3. PMID 9118953, Free PMC Article
    2. BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes. Di Pietro SM, et al. Mol Biol Cell, 2006 Sep. PMID 16837549, Free PMC Article
    3. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, et al. Proc Natl Acad Sci U S A, 2020 Dec 29. PMID 33376223, Free PMC Article
    4. The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Larimore J, et al. Mol Biol Cell, 2011 Dec. PMID 21998198, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anterograde axonal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anterograde synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AP-3 complex subunit sigma-1
    Names
    adaptor-related protein complex 3, sigma 1 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398640.1 → NP_001385569.1  AP-3 complex subunit sigma-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6IWX1
      Related
      ENSRNOP00000086040.2, ENSRNOT00000112095.2
      Conserved Domains (1) summary
      cd14834
      Location:1 → 146
      AP3_sigma; AP-3 complex subunit sigma

    2. NM_001398641.1 → NP_001385570.1  AP-3 complex subunit sigma-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      G3V9Y9
      Related
      ENSRNOP00000063471.2, ENSRNOT00000064116.3
      Conserved Domains (1) summary
      cd14834
      Location:1 → 146
      AP3_sigma; AP-3 complex subunit sigma

    3. NM_001398642.1 → NP_001385571.1  AP-3 complex subunit sigma-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      B2RZ62
      Related
      ENSRNOP00000087147.1, ENSRNOT00000098846.2
      Conserved Domains (1) summary
      cd14834
      Location:1 → 146
      AP3_sigma; AP-3 complex subunit sigma

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      41649321..41718221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277281.1 → XP_063133351.1  AP-3 complex subunit sigma-1 isoform X1

    RNA

    1. XR_005496019.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106933.1: Suppressed sequence

      Description
      NM_001106933.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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