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    Ackr1 atypical chemokine receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689105, updated on 9-Dec-2024

    Summary

    Symbol
    Ackr1provided by RGD
    Full Name
    atypical chemokine receptor 1provided by RGD
    Primary source
    RGD:1596198
    See related
    EnsemblRapid:ENSRNOG00000069330 AllianceGenome:RGD:1596198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Darc
    Summary
    Predicted to enable C-C chemokine binding activity. Predicted to be involved in chemokine-mediated signaling pathway. Predicted to act upstream of or within inflammatory response and regulation of chemokine production. Predicted to be located in early endosome; membrane; and recycling endosome. Human ortholog(s) of this gene implicated in Plasmodium vivax malaria and malaria. Orthologous to human ACKR1 (atypical chemokine receptor 1 (Duffy blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 43.4), Brain (RPKM 43.0) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Ackr1 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (88314735..88316354, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (85782396..85784015, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (91827310..91828875, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily J member 2 Neighboring gene mucosal pentraxin 1 Neighboring gene cell adhesion molecule 3 Neighboring gene transfer RNA arginine (anticodon UCU) 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chemokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    atypical chemokine receptor 1
    Names
    Duffy blood group, atypical chemokine receptor
    Duffy blood group, chemokine receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398729.1NP_001385658.1  atypical chemokine receptor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I5ZL85, A6JG85
      Related
      ENSRNOP00000078656.1, ENSRNOT00000117393.2
      Conserved Domains (1) summary
      cd15010
      Location:58314
      7tmA_ACKR1_DARC; Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      88314735..88316354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)