Gabpb1 GA binding protein transcription factor subunit beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabpb1provided by RGD
Official Full Name: GA binding protein transcription factor subunit beta 1provided by RGD
Primary source: RGD:1560391
See related: EnsemblRapid:ENSRNOG00000010659 AllianceGenome:RGD:1560391
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560391
Summary: Predicted to enable transcription cis-regulatory region binding activity. Predicted to be involved in mitochondrion organization and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Predicted to be active in nucleus. Orthologous to human GABPB1 (GA binding protein transcription factor subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 113.0), Lung (RPKM 79.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (134333339..134380239, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (113879972..113924742, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (119091739..119135391, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH130763 (e-PCR)
- UniSTS:214047

RH137091 (e-PCR)
- UniSTS:219179

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GA-binding protein subunit beta-1

Names: GA binding protein transcription factor, beta subunit 1; GA repeat binding protein, beta 1

NP_001034125.1

EC 3.2.1.3

NP_001385852.1

EC 3.2.1.3

NP_001385853.1

EC 3.2.1.3

XP_008760411.1

EC 3.2.1.3

XP_008760412.1

EC 3.2.1.3

XP_017447471.1

EC 3.2.1.3

XP_017447472.1

EC 3.2.1.3

XP_017447473.1

EC 3.2.1.3

XP_038961617.1

EC 3.2.1.3

XP_063140441.1

EC 3.2.1.3

XP_063140442.1

EC 3.2.1.3

XP_063140443.1

EC 3.2.1.3

XP_063140444.1

EC 3.2.1.3

XP_063140445.1

EC 3.2.1.3

XP_063140446.1

EC 3.2.1.3

XP_063140447.1

EC 3.2.1.3

XP_063140448.1

EC 3.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039036.2 → NP_001034125.1 GA-binding protein subunit beta-1 isoform 1

See identical proteins and their annotated locations for NP_001034125.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2K5B7, Q4KM28

Related

ENSRNOP00000078447.1, ENSRNOT00000109155.2

Conserved Domains (3) summary

sd00045
Location:38 → 68

ANK; ANK repeat [structural motif]

pfam12796
Location:42 → 133

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:10 → 58

Ank_4; Ankyrin repeats (many copies)
NM_001398923.1 → NP_001385852.1 GA-binding protein subunit beta-1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6HPY8

Conserved Domains (4) summary

sd00045
Location:38 → 68

ANK; ANK repeat [structural motif]

pfam13637
Location:10 → 58

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:42 → 133

Ank_2; Ankyrin repeats (3 copies)

pfam16566
Location:329 → 378

CREPT; Cell-cycle alteration and expression-elevated protein in tumor
NM_001398924.1 → NP_001385853.1 GA-binding protein subunit beta-1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZWD2

Conserved Domains (3) summary

sd00045
Location:38 → 68

ANK; ANK repeat [structural motif]

pfam13637
Location:10 → 58

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:42 → 133

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

134333339..134380239 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105689.2 → XP_038961617.1 GA-binding protein subunit beta-1 isoform X1

UniProtKB/TrEMBL

A6HPY8

Conserved Domains (4) summary

sd00045
Location:38 → 68

ANK; ANK repeat [structural motif]

pfam13637
Location:10 → 58

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:42 → 133

Ank_2; Ankyrin repeats (3 copies)

pfam16566
Location:329 → 378

CREPT; Cell-cycle alteration and expression-elevated protein in tumor
XM_063284375.1 → XP_063140445.1 GA-binding protein subunit beta-1 isoform X6
XM_063284377.1 → XP_063140447.1 GA-binding protein subunit beta-1 isoform X8
XM_017591984.3 → XP_017447473.1 GA-binding protein subunit beta-1 isoform X5

Conserved Domains (3) summary

sd00045
Location:10 → 35

ANK; ANK repeat [structural motif]

pfam12796
Location:10 → 92

Ank_2; Ankyrin repeats (3 copies)

pfam16566
Location:264 → 313

CREPT; Cell-cycle alteration and expression-elevated protein in tumor
XM_063284376.1 → XP_063140446.1 GA-binding protein subunit beta-1 isoform X7
XM_017591983.3 → XP_017447472.1 GA-binding protein subunit beta-1 isoform X2

Conserved Domains (4) summary

sd00045
Location:38 → 68

ANK; ANK repeat [structural motif]

pfam13637
Location:10 → 58

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:42 → 133

Ank_2; Ankyrin repeats (3 copies)

pfam16566
Location:328 → 377

CREPT; Cell-cycle alteration and expression-elevated protein in tumor
XM_063284374.1 → XP_063140444.1 GA-binding protein subunit beta-1 isoform X4
XM_008762190.4 → XP_008760412.1 GA-binding protein subunit beta-1 isoform X3

UniProtKB/TrEMBL

A0A0G2K5B7, A0A8I5ZWD2

Related

ENSRNOP00000045035.5, ENSRNOT00000045443.7

Conserved Domains (3) summary

sd00045
Location:38 → 68

ANK; ANK repeat [structural motif]

pfam13637
Location:10 → 58

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:42 → 133

Ank_2; Ankyrin repeats (3 copies)
XM_063284372.1 → XP_063140442.1 GA-binding protein subunit beta-1 isoform X2
XM_017591982.3 → XP_017447471.1 GA-binding protein subunit beta-1 isoform X1

UniProtKB/TrEMBL

A6HPY8

Conserved Domains (4) summary

sd00045
Location:38 → 68

ANK; ANK repeat [structural motif]

pfam13637
Location:10 → 58

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:42 → 133

Ank_2; Ankyrin repeats (3 copies)

pfam16566
Location:329 → 378

CREPT; Cell-cycle alteration and expression-elevated protein in tumor
XM_063284373.1 → XP_063140443.1 GA-binding protein subunit beta-1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZWD2
XM_063284378.1 → XP_063140448.1 GA-binding protein subunit beta-1 isoform X9
XM_008762189.3 → XP_008760411.1 GA-binding protein subunit beta-1 isoform X1

See identical proteins and their annotated locations for XP_008760411.1

UniProtKB/TrEMBL

A6HPY8

Conserved Domains (4) summary

sd00045
Location:38 → 68

ANK; ANK repeat [structural motif]

pfam13637
Location:10 → 58

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:42 → 133

Ank_2; Ankyrin repeats (3 copies)

pfam16566
Location:329 → 378

CREPT; Cell-cycle alteration and expression-elevated protein in tumor
XM_063284371.1 → XP_063140441.1 GA-binding protein subunit beta-1 isoform X2