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    Ucma upper zone of growth plate and cartilage matrix associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291312, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ucmaprovided by RGD
    Official Full Name
    upper zone of growth plate and cartilage matrix associatedprovided by RGD
    Primary source
    RGD:1308977
    See related
    EnsemblRapid:ENSRNOG00000017987 AllianceGenome:RGD:1308977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GRP; RGD1308977
    Summary
    Predicted to enable BMP binding activity. Predicted to be involved in embryonic skeletal system development and negative regulation of SMAD protein signal transduction. Predicted to act upstream of or within negative regulation of osteoblast differentiation. Predicted to be located in cytoplasm. Predicted to be active in extracellular matrix. Orthologous to human UCMA (upper zone of growth plate and cartilage matrix associated). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 10.5), Adrenal (RPKM 8.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ucma in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (78203268..78212996, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (73293977..73303709, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (77252099..77262301, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene optineurin Neighboring gene uncharacterized LOC134482742 Neighboring gene minichromosome maintenance 10 replication initiation factor Neighboring gene uncharacterized LOC120097916 Neighboring gene phytanoyl-CoA 2-hydroxylase Neighboring gene selenophosphate synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of four alternatively spliced transcripts of the Ucma/GRP gene, encoding a new Gla-containing protein. Le Jeune M, et al. Exp Cell Res, 2010 Jan 15. PMID 19819238
    2. Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling. Willems BA, et al. Sci Rep, 2018 Mar 21. PMID 29563538, Free PMC Article
    3. Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis. Surmann-Schmitt C, et al. J Biol Chem, 2008 Mar 14. PMID 18156182
    4. Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. Viegas CS, et al. J Biol Chem, 2008 Dec 26. PMID 18836183, Free PMC Article
    5. Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes. Tagariello A, et al. Matrix Biol, 2008 Jan. PMID 17707622

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables BMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    unique cartilage matrix-associated protein
    Names
    Gla-rich protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399350.1 → NP_001386279.1  unique cartilage matrix-associated protein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      B9TQX4
      Related
      ENSRNOP00000086256.1, ENSRNOT00000095251.2
      Conserved Domains (1) summary
      pfam17085
      Location:1 → 134
      UCMA; Unique cartilage matrix associated protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      78203268..78212996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106121.1: Suppressed sequence

      Description
      NM_001106121.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B9TQX4.1 GenPept UniProtKB/Swiss-Prot:B9TQX4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials