U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Ercc6l2 ERCC excision repair 6 like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361197, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ercc6l2provided by RGD
    Official Full Name
    ERCC excision repair 6 like 2provided by RGD
    Primary source
    RGD:1561537
    See related
    EnsemblRapid:ENSRNOG00000019175 AllianceGenome:RGD:1561537
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561537
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in cellular response to reactive oxygen species and interstrand cross-link repair. Predicted to be located in several cellular components, including centrosome; mitochondrion; and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human ERCC6L2 (ERCC excision repair 6 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 203.3), Thymus (RPKM 197.7) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ercc6l2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (1055881..1323207, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (1076486..1311281, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (1325654..1421732)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 367 Neighboring gene solute carrier family 35 member D2 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 3 Neighboring gene uncharacterized LOC102554174 Neighboring gene uncharacterized LOC134482763 Neighboring gene ribosomal protein L27a, pseudogene 8

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function. Tummala H, et al. Am J Hum Genet, 2014 Feb 6. PMID 24507776, Free PMC Article
    2. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. Vaz Meirelles G, et al. J Proteome Res, 2010 Dec 3. PMID 20873783
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA excision repair protein ERCC-6-like 2
    Names
    excision repair cross-complementation group 6-like 2
    excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400699.1 → NP_001387628.1  DNA excision repair protein ERCC-6-like 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6KQC8, D3ZPU4
      Related
      ENSRNOP00000025965.6, ENSRNOT00000025965.11

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      1055881..1323207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096261.2 → XP_038952189.1  DNA excision repair protein ERCC-6-like 2 isoform X4

      Conserved Domains (3) summary
      COG0553
      Location:9 → 649
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18005
      Location:122 → 369
      DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
      pfam14773
      Location:1132 → 1155
      VIGSSK; Helicase-associated putative binding domain, C-terminal

    2. XM_063276550.1 → XP_063132620.1  DNA excision repair protein ERCC-6-like 2 isoform X5

    3. XM_039096260.2 → XP_038952188.1  DNA excision repair protein ERCC-6-like 2 isoform X3

      Conserved Domains (3) summary
      COG0553
      Location:9 → 649
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18005
      Location:122 → 369
      DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
      pfam14773
      Location:1132 → 1155
      VIGSSK; Helicase-associated putative binding domain, C-terminal

    4. XM_039096259.2 → XP_038952187.1  DNA excision repair protein ERCC-6-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KQC8
      Related
      ENSRNOP00000112864.1, ENSRNOT00000138029.1
      Conserved Domains (3) summary
      COG0553
      Location:9 → 649
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18005
      Location:122 → 369
      DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
      pfam14773
      Location:1132 → 1155
      VIGSSK; Helicase-associated putative binding domain, C-terminal

    5. XM_063276549.1 → XP_063132619.1  DNA excision repair protein ERCC-6-like 2 isoform X2

      UniProtKB/TrEMBL
      A6KQC8

    6. XM_039096262.2 → XP_038952190.1  DNA excision repair protein ERCC-6-like 2 isoform X6

      Conserved Domains (2) summary
      cd18793
      Location:1 → 123
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam14773
      Location:625 → 648
      VIGSSK; Helicase-associated putative binding domain, C-terminal

    7. XM_039096263.2 → XP_038952191.1  DNA excision repair protein ERCC-6-like 2 isoform X7

      Conserved Domains (2) summary
      COG0553
      Location:73 → 466
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cl28899
      Location:41 → 254
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    RNA

    1. XR_010058894.1 RNA Sequence

    2. XR_010058892.1 RNA Sequence

    3. XR_010058893.1 RNA Sequence

    4. XR_005495504.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools