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    strl-1 START domain-containing protein;Steroidogenic acute regulatory-like protein 1 [ Caenorhabditis elegans ]

    Gene ID: 172846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    strl-1
    Official Full Name
    START domain-containing protein;Steroidogenic acute regulatory-like protein 1
    Primary source
    WormBase:WBGene00009940
    Locus tag
    CELE_F52F12.7
    See related
    AllianceGenome:WB:WBGene00009940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lipid binding activity. Predicted to be involved in vesicle tethering to endoplasmic reticulum. Predicted to be active in endoplasmic reticulum-endosome membrane contact site and late endosome membrane. Predicted to colocalize with endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human STAR (steroidogenic acute regulatory protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See strl-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (9928993..9930885)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene Methyltranfer_dom domain-containing protein Neighboring gene BAR domain-containing protein Neighboring gene MRG domain-containing protein Neighboring gene Dysbindin protein homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BPA interferes with StAR-mediated mitochondrial cholesterol transport to induce germline dysfunctions. Chen Y, et al. Reprod Toxicol, 2019 Dec. PMID 31445225, Free PMC Article
    2. GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in C. elegans. Wu J, et al. Sci Adv, 2022 Dec 21. PMID 36542715, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in vesicle tethering to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-endosome membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    START domain-containing protein;Steroidogenic acute regulatory-like protein 1
    NP_001251250.1
    • Confirmed by transcript evidence
    NP_001251251.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9928993..9930885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001264321.3 → NP_001251250.1  Steroidogenic acute regulatory-like protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251250.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17883
      Conserved Domains (1) summary
      pfam01852
      Location:52 → 255
      START; START domain

    2. NM_001264322.2 → NP_001251251.1  START domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251251.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GUI0
      Conserved Domains (1) summary
      pfam01852
      Location:34 → 237
      START; START domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17883.2

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