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    Rap1gap2 RAP1 GTPase activating protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 380711, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rap1gap2provided by MGI
    Official Full Name
    RAP1 GTPase activating protein 2provided by MGI
    Primary source
    MGI:MGI:3028623
    See related
    Ensembl:ENSMUSG00000038807 AllianceGenome:MGI:3028623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Garnl4; Gm1561; mKIAA1039
    Summary
    Enables GTPase activator activity. Acts upstream of or within negative regulation of neuron projection development. Located in cytoplasm and neuron projection. Is expressed in olfactory epithelium; pancreas; and telencephalon. Orthologous to human RAP1GAP2 (RAP1 GTPase activating protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 24.4), frontal lobe adult (RPKM 21.6) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rap1gap2 in Genome Data Viewer
    Location:
    11 B5; 11 45.76 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74274182..74501796, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74383356..74610915, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 3 subfamily A member 1D Neighboring gene olfactory receptor family 1 subfamily D member 2 Neighboring gene STARR-positive B cell enhancer ABC_E7014 Neighboring gene STARR-seq mESC enhancer starr_29957 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:74369680-74369789 Neighboring gene STARR-seq mESC enhancer starr_29960 Neighboring gene STARR-seq mESC enhancer starr_29961 Neighboring gene STARR-seq mESC enhancer starr_29962 Neighboring gene predicted gene, 50590 Neighboring gene coiled-coil domain containing 92B Neighboring gene STARR-positive B cell enhancer ABC_E3971 Neighboring gene clustered mitochondria homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC130388

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    rap1 GTPase-activating protein 2
    Names
    GTPase activating RANGAP domain-like 4
    GTPase-activating Rap/Ran-GAP domain-like protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015046.3NP_001015046.1  rap1 GTPase-activating protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001015046.1

      Status: VALIDATED

      Source sequence(s)
      AK038834, AK147290, AL604065, AW457490, CJ106176
      Consensus CDS
      CCDS25032.1
      UniProtKB/Swiss-Prot
      Q3KNA3, Q3V3L0, Q5SVL6, Q80TL8
      UniProtKB/TrEMBL
      A0A171EBK8
      Related
      ENSMUSP00000099580.2, ENSMUST00000102521.9
      Conserved Domains (1) summary
      pfam02145
      Location:259438
      Rap_GAP; Rap/ran-GAP
    2. NM_001364131.1NP_001351060.1  rap1 GTPase-activating protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL604065, AL627348
      UniProtKB/TrEMBL
      A0A171EBK8
      Conserved Domains (1) summary
      pfam02145
      Location:287466
      Rap_GAP; Rap/ran-GAP
    3. NM_001364132.1NP_001351061.1  rap1 GTPase-activating protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL604065, AL627348, AL645971
      UniProtKB/TrEMBL
      A0A171EBK8
      Conserved Domains (1) summary
      pfam02145
      Location:257436
      Rap_GAP; Rap/ran-GAP
    4. NM_001401658.1NP_001388587.1  rap1 GTPase-activating protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL604065, AL627348

    RNA

    1. NR_157089.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL604065, AL627348, AL645971
      Related
      ENSMUST00000047488.15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      74274182..74501796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533622.4XP_006533685.2  rap1 GTPase-activating protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A171EBK8, A0A571BED8
      Related
      ENSMUSP00000158689.2, ENSMUST00000238457.2
      Conserved Domains (1) summary
      pfam02145
      Location:319498
      Rap_GAP; Rap/ran-GAP
    2. XM_036156817.1XP_036012710.1  rap1 GTPase-activating protein 2 isoform X9

      Conserved Domains (1) summary
      pfam02145
      Location:210389
      Rap_GAP; Rap/ran-GAP
    3. XM_036156816.1XP_036012709.1  rap1 GTPase-activating protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A171EBK8
      Conserved Domains (1) summary
      pfam02145
      Location:225404
      Rap_GAP; Rap/ran-GAP
    4. XM_030246102.2XP_030101962.1  rap1 GTPase-activating protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A171EBK8
      Conserved Domains (1) summary
      pfam02145
      Location:244423
      Rap_GAP; Rap/ran-GAP
    5. XM_006533624.3XP_006533687.1  rap1 GTPase-activating protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A171EBK8
      Conserved Domains (1) summary
      pfam02145
      Location:337516
      Rap_GAP; Rap/ran-GAP
    6. XM_006533628.3XP_006533691.1  rap1 GTPase-activating protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A171EBK8
      Conserved Domains (1) summary
      pfam02145
      Location:256435
      Rap_GAP; Rap/ran-GAP
    7. XM_006533629.3XP_006533692.1  rap1 GTPase-activating protein 2 isoform X6

      Conserved Domains (1) summary
      pfam02145
      Location:232411
      Rap_GAP; Rap/ran-GAP
    8. XM_006533631.4XP_006533694.1  rap1 GTPase-activating protein 2 isoform X8

      Conserved Domains (1) summary
      pfam02145
      Location:217396
      Rap_GAP; Rap/ran-GAP