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    MEIS2 Meis homeobox 2 [ Gallus gallus (chicken) ]

    Gene ID: 395588, updated on 3-Dec-2024

    Summary

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    Official Symbol
    MEIS2provided by CGNC
    Official Full Name
    Meis homeobox 2provided by CGNC
    Primary source
    CGNC:49388
    See related
    Ensembl:ENSGALG00010005359
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    Meis2a.1; Meis2a.2
    Orthologs
    human mouse all
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    Genomic context

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    See MEIS2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (30721053..30891982)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (30702269..30873317)

    Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124418039 Neighboring gene uncharacterized LOC124418016 Neighboring gene uncharacterized LOC112532577 Neighboring gene uncharacterized LOC107053500 Neighboring gene microRNA 1718 Neighboring gene CDAN1 interacting nuclease 1 Neighboring gene uncharacterized LOC124417973

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct and redundant expression and transcriptional diversity of MEIS gene paralogs during chicken development. Sánchez-Guardado LÓ, et al. Dev Dyn, 2011 Jun. PMID 21465619
    2. Meis gene expression patterns in the developing chicken inner ear. Sánchez-Guardado LÓ, et al. J Comp Neurol, 2011 Jan 1. PMID 21120931
    3. Sonic hedgehog signaling in the chick retina accelerates Meis2 downregulation simultaneously with retinal ganglion cell genesis. Heine P, et al. Neuroreport, 2009 Feb 18. PMID 19188860
    4. Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. Agoston Z, et al. BMC Dev Biol, 2012 Mar 5. PMID 22390724, Free PMC Article
    5. Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Capdevila J, et al. Mol Cell, 1999 Nov. PMID 10619030

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression.
      Title: Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development.
    2. Detailed analysis of chick Meis1/2 expression patterns during early embryogenesis and organogenesis.
      Title: Distinct and redundant expression and transcriptional diversity of MEIS gene paralogs during chicken development.
    3. Our results suggest a possible role of Meis assigning regional identity in the morphogenesis, patterning, and specification of the developing inner ear.
      Title: Meis gene expression patterns in the developing chicken inner ear.
    4. Hth expression in the fly eye imaginal disc is primarily repressed by the transforming growth factor beta family protein decapentaplegic, whereas Meis2 expression in the chick eye cup is terminated in response to sonic hedgehog signaling.
      Title: Sonic hedgehog signaling in the chick retina accelerates Meis2 downregulation simultaneously with retinal ganglion cell genesis.
    5. Retinal progenitor cells (RPCs) in chicks and mice express two Hth-related proteins, Meis1 and Meis2.
      Title: Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in embryonic pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in eye development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein Meis2
    Names
    Meis1, myeloid ecotropic viral integration site 1 homolog 2
    homeoprotein Meis2a.1
    homeoprotein Meis2a.2
    myeloid ecotropic viral insertion site-2a protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001397970.1 → NP_001384899.1  homeobox protein Meis2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      A0A8V0XGM9, Q9PTH1
      Related
      ENSGALP00010007300.1, ENSGALT00010012736.1

    2. NM_001397971.1 → NP_001384900.1  homeobox protein Meis2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q9PTF0

    3. NM_001397972.1 → NP_001384901.1  homeobox protein Meis2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      A0A8V0XGP4
      Related
      ENSGALP00010007315.1, ENSGALT00010012751.1
      Conserved Domains (2) summary
      pfam05920
      Location:328 → 367
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:110 → 194
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    4. NM_001397973.1 → NP_001384902.1  homeobox protein Meis2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      A0A8V0XGP4
      Conserved Domains (1) summary
      cd00086
      Location:314 → 367
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    5. NM_001397974.1 → NP_001384903.1  homeobox protein Meis2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      A0A8V0XGP4

    6. NM_001397976.1 → NP_001384905.1  homeobox protein Meis2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q9PTH1
      Conserved Domains (1) summary
      cd00086
      Location:291 → 344
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    7. NM_001397978.1 → NP_001384907.1  homeobox protein Meis2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q9PTF0
      Conserved Domains (2) summary
      pfam05920
      Location:305 → 344
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:121 → 205
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    8. NM_001397979.1 → NP_001384908.1  homeobox protein Meis2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q9PTH1
      Conserved Domains (2) summary
      pfam05920
      Location:293 → 332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:109 → 193
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    9. NM_001397980.1 → NP_001384909.1  homeobox protein Meis2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      A0A1D5PZF4, F5ANJ4, Q9PTF0
      Conserved Domains (2) summary
      pfam05920
      Location:294 → 333
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:110 → 194
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    10. NM_001397981.1 → NP_001384910.1  homeobox protein Meis2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      A0A8V0XTD0
      Conserved Domains (2) summary
      pfam05920
      Location:293 → 332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:109 → 193
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    11. NM_001397982.1 → NP_001384911.1  homeobox protein Meis2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      A0A8V0XTD0
      Related
      ENSGALP00010007291.1, ENSGALT00010012727.1
      Conserved Domains (2) summary
      pfam05920
      Location:293 → 332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:109 → 193
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    12. NM_001397983.1 → NP_001384912.1  homeobox protein Meis2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q9PTH1
      Conserved Domains (2) summary
      pfam05920
      Location:281 → 320
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:97 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    13. NM_001397984.1 → NP_001384913.1  homeobox protein Meis2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q9PTH1
      Conserved Domains (2) summary
      pfam05920
      Location:281 → 320
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:97 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    14. NM_001397985.1 → NP_001384914.1  homeobox protein Meis2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q9PTH1
      Conserved Domains (2) summary
      pfam05920
      Location:281 → 320
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:97 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    15. NM_001397986.1 → NP_001384915.1  homeobox protein Meis2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q9PTF0
      Conserved Domains (2) summary
      pfam05920
      Location:281 → 320
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:97 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    16. NM_001397987.1 → NP_001384916.1  homeobox protein Meis2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q9PTF0
      Conserved Domains (2) summary
      pfam05920
      Location:281 → 320
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:97 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    17. NM_204803.2 → NP_990134.2  homeobox protein Meis2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      F5ANJ3, Q9PTH1
      Related
      ENSGALP00010007318.1, ENSGALT00010012754.1
      Conserved Domains (2) summary
      pfam05920
      Location:294 → 333
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:110 → 194
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      30721053..30891982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046941379.1 → XP_046797335.1  homeobox protein Meis2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XGP4

    2. XM_046941380.1 → XP_046797336.1  homeobox protein Meis2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XGP4

    3. XM_046941381.1 → XP_046797337.1  homeobox protein Meis2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XGP4

    4. XM_040700585.2 → XP_040556519.2  homeobox protein Meis2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0XGP4

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      30702269..30873317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046917704.1 → XP_046773660.1  homeobox protein Meis2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XGP4

    2. XM_046917705.1 → XP_046773661.1  homeobox protein Meis2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XGP4

    3. XM_046917706.1 → XP_046773662.1  homeobox protein Meis2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XGP4

    4. XM_046917707.1 → XP_046773663.1  homeobox protein Meis2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0XGP4
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials