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    ATM ATM serine/threonine kinase [ Gallus gallus (chicken) ]

    Gene ID: 395401, updated on 3-Dec-2024

    Summary

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    Symbol
    ATMprovided by CGNC
    Full Name
    ATM serine/threonine kinaseprovided by CGNC
    Primary source
    CGNC:12888
    See related
    Ensembl:ENSGALG00010004824
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ATM in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    64
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (180132376..180192071, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (180164989..180224719, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121113484 Neighboring gene KDEL motif containing 2 Neighboring gene uncharacterized LOC121109181 Neighboring gene nuclear protein, coactivator of histone transcription Neighboring gene acetyl-CoA acetyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation. Takao N, et al. Oncogene, 1999 Nov 25. PMID 10597300
    2. ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells. Ren S, et al. PLoS Pathog, 2020 Jun. PMID 32479542, Free PMC Article
    3. DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos. Montero JA, et al. Sci Rep, 2016 Oct 18. PMID 27752097, Free PMC Article
    4. Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags. Hubbard SJ, et al. Genome Res, 2005 Jan. PMID 15590942, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells.
      Title: ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells.
    2. Phosphorylation of H2AX mediated by ATM precedes caspase dependent apoptosis and cell senescence during interdigit regression.
      Title: DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine-protein kinase ATM
    Names
    ATM (ataxia telangiectasia mutated)
    ataxia telangiectasia mutated (includes complementation groups A, C and D)
    NP_001155872.2
    XP_015133057.2
    XP_015133060.2
    XP_025010375.2
    XP_025010397.2
    XP_025010458.2
    XP_040502432.1
    XP_040502482.1
    XP_040502525.1
    XP_046762513.1
    XP_046762514.1
    XP_046762515.1
    XP_046762516.1
    XP_046762517.1
    XP_046762518.1
    XP_046762519.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162400.2 → NP_001155872.2  serine-protein kinase ATM

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000027
      UniProtKB/TrEMBL
      A0A8V0XNG7

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      180132376..180192071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040646498.2 → XP_040502432.1  serine-protein kinase ATM isoform X3

      UniProtKB/TrEMBL
      A0A8V0XNG7
      Conserved Domains (2) summary
      COG5032
      Location:1887 → 3017
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05171
      Location:2645 → 2924
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated

    2. XM_015277574.4 → XP_015133060.2  serine-protein kinase ATM isoform X2

      UniProtKB/TrEMBL
      A0A8V0XNG7
      Related
      ENSGALP00010006360.1, ENSGALT00010011290.1
      Conserved Domains (2) summary
      COG5032
      Location:2008 → 3068
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05171
      Location:2697 → 2976
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated

    3. XM_015277571.4 → XP_015133057.2  serine-protein kinase ATM isoform X1

      UniProtKB/TrEMBL
      A0A8V0XI18, A0A8V0XNG7
      Related
      ENSGALP00010006351.1, ENSGALT00010011261.1
      Conserved Domains (2) summary
      COG5032
      Location:2008 → 3069
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05171
      Location:2697 → 2976
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated

    4. XM_040646548.2 → XP_040502482.1  serine-protein kinase ATM isoform X4

      UniProtKB/TrEMBL
      A0A8V0XNG7
      Conserved Domains (2) summary
      COG5032
      Location:1586 → 2647
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05171
      Location:2275 → 2554
      PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated

    5. XM_040646591.2 → XP_040502525.1  serine-protein kinase ATM isoform X5

    6. XM_025154607.3 → XP_025010375.2  serine-protein kinase ATM isoform X6

    7. XM_025154629.3 → XP_025010397.2  serine-protein kinase ATM isoform X7

    8. XM_025154690.3 → XP_025010458.2  serine-protein kinase ATM isoform X8

    RNA

    1. XR_003077418.3 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      180164989..180224719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046906559.1 → XP_046762515.1  serine-protein kinase ATM isoform X3

      UniProtKB/TrEMBL
      A0A8V0XNG7

    2. XM_046906558.1 → XP_046762514.1  serine-protein kinase ATM isoform X2

      UniProtKB/TrEMBL
      A0A8V0XNG7

    3. XM_046906557.1 → XP_046762513.1  serine-protein kinase ATM isoform X1

      UniProtKB/TrEMBL
      A0A8V0XNG7

    4. XM_046906560.1 → XP_046762516.1  serine-protein kinase ATM isoform X5

    5. XM_046906561.1 → XP_046762517.1  serine-protein kinase ATM isoform X6

    6. XM_046906562.1 → XP_046762518.1  serine-protein kinase ATM isoform X7

    7. XM_046906563.1 → XP_046762519.1  serine-protein kinase ATM isoform X8

    RNA

    1. XR_006932632.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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