MBL2 mannose binding lectin 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: MBL2provided by CGNC
Full Name: mannose binding lectin 2provided by CGNC
Primary source: CGNC:49110
See related: Ensembl:ENSGALG00010011044
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: MBL; MBP; cMBl; collectin
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Genomic context

Location:: chromosome: 6

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	6	NC_052537.1 (5175151..5202549, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	6	NC_052578.1 (5059703..5088334, complement)

Chromosome 6 - NC_052537.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the negative control birds, the spleen was mannose-binding lectin (MBL) negative, while the caecal tonsil showed scattered MBL-positive cells in close proximity and within the surface epithelium and germinal centre-like cell clusters. MBL was detectable in the ellipsoid-associated cells and cell clusters in the periarterial lymphoid sheath by 7 days post infection.
Title: Avian coronavirus infection induces mannose-binding lectin production in dendritic cell precursors of chicken lymphoid organs.
In chickens, six different collagenous lectins have been characterized so far: mannose-binding lectin (MBL), surfactant protein A (SP-A), collectin 10 (COLEC10), collectin 11 (COLEC11), collectin 12 (COLEC12), lung lectin (LL) and one ficolin (FCN).
Title: Annotation and genetic diversity of the chicken collagenous lectins.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in positive regulation of phagocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in surfactant homeostasis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in multivesicular body	IEA Inferred from Electronic Annotation more info	PubMed
located_in rough endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mannose-binding lectin

Names: MBL-C; c-type lectin; mannan-binding lectin; mannan-binding protein; mannose binding lectin, liver (A); mannose-binding lectin protein; mannose-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204349.3 → NP_989680.3 mannose-binding lectin precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000227

UniProtKB/TrEMBL

A0A173G7D1, A0A8V0YGD5

Conserved Domains (2) summary

cd03591
Location:142 → 254

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam09006
Location:105 → 149

Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerisation

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

5175151..5202549 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040702220.2 → XP_040558154.1 mannose-binding lectin isoform X2

UniProtKB/TrEMBL

A0A8V0Y9H2

Related

ENSGALP00010015062.1, ENSGALT00010026460.1

Conserved Domains (2) summary

cd03591
Location:201 → 313

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam09006
Location:164 → 208

Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerisation
XM_040702219.2 → XP_040558153.1 mannose-binding lectin isoform X1

Conserved Domains (2) summary

cd03591
Location:235 → 347

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam09006
Location:198 → 242

Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerisation
XM_040702218.2 → XP_040558152.1 mannose-binding lectin isoform X1

Conserved Domains (2) summary

cd03591
Location:235 → 347

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam09006
Location:198 → 242

Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerisation
XM_040702221.2 → XP_040558155.1 mannose-binding lectin isoform X3

UniProtKB/TrEMBL

A0A173G7D1, A0A8V0YGD5

Conserved Domains (2) summary

cd03591
Location:142 → 254

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam09006
Location:105 → 149

Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerisation
XM_040702223.2 → XP_040558157.1 mannose-binding lectin isoform X3

UniProtKB/TrEMBL

A0A173G7D1, A0A8V0YGD5

Related

ENSGALP00010015061.1, ENSGALT00010026456.1

Conserved Domains (2) summary

cd03591
Location:142 → 254

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam09006
Location:105 → 149

Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerisation
XM_046942695.1 → XP_046798651.1 mannose-binding lectin isoform X4

UniProtKB/TrEMBL

A0A8V0Y7X3

Related

ENSGALP00010015059.1, ENSGALT00010026454.1