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    ND-MWFE NADH dehydrogenase (ubiquinone) MWFE subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740593, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ND-MWFEprovided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) MWFE subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085468
    Locus tag
    Dmel_CG34439
    See related
    AllianceGenome:FB:FBgn0085468
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH49308; CG13328; CG17054; CG30057; CG34439; Dmel\CG34439; dNDUFA1; l(2)c00093; NDUFA1
    Summary
    Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 12. Orthologous to human NDUFA1 (NADH:ubiquinone oxidoreductase subunit A1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See ND-MWFE in Genome Data Viewer
    Location:
    49F4-49F4; 2-68 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13158666..13160190)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9046171..9047695)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Chromosome associated protein G Neighboring gene Activated Cdc42 kinase-like Neighboring gene Tripeptidyl-peptidase II Neighboring gene Neurospecific receptor kinase Neighboring gene uncharacterized protein Neighboring gene Glial Lazarillo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster. Holland C, et al. Genetics, 2011 Jun. PMID 21441212, Free PMC Article
    2. Conservation of an RNA regulatory map between Drosophila and mammals. Brooks AN, et al. Genome Res, 2011 Feb. PMID 20921232, Free PMC Article
    3. SR proteins control a complex network of RNA-processing events. Bradley T, et al. RNA, 2015 Jan. PMID 25414008, Free PMC Article
    4. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article
    5. Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity. Murari A, et al. Cell Rep, 2023 Aug 29. PMID 37516961, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) MWFE subunit
    Names
    CG34439-PA
    CG34439-PB
    NADH ubiquinone oxidoreductase MWFE
    ND-MWFE-PA
    ND-MWFE-PB
    lethal (2) c00093

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13158666..13160190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103827.2 → NP_001097297.1  NADH dehydrogenase (ubiquinone) MWFE subunit, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYC4
      Conserved Domains (2) summary
      pfam08496
      Location:93 → 119
      Peptidase_S49_N; Peptidase family S49 N-terminal
      pfam15879
      Location:4 → 55
      MWFE; NADH-ubiquinone oxidoreductase MWFE subunit

    2. NM_001103826.2 → NP_001097296.1  NADH dehydrogenase (ubiquinone) MWFE subunit, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYC5, Q8SXW2
      Conserved Domains (1) summary
      pfam15879
      Location:4 → 55
      MWFE; NADH-ubiquinone oxidoreductase MWFE subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYC4 A8DYC4
    A8DYC5 A8DYC5

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