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    metro menage a trois [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36176, updated on 9-Dec-2024

    Summary

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    Official Symbol
    metroprovided by FlyBase
    Official Full Name
    menage a troisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050021
    Locus tag
    Dmel_CG30021
    See related
    AllianceGenome:FB:FBgn0050021
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13219; CG18338; CG30021; Dmel\CG30021; FBgn0050021; met; Metro
    Summary
    Involved in regulation of synaptic assembly at neuromuscular junction. Located in subsynaptic reticulum. Is expressed in several structures, including CNS glial cell; adult head; adult heart; central brain primordium; and ganglia. Orthologous to several human genes including MPP3 (MAGUK p55 scaffold protein 3) and MPP7 (MAGUK p55 scaffold protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See metro in Genome Data Viewer
    Location:
    47E1-47E1; 2-64 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11226458..11232516, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7113963..7120021, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene schnurri Neighboring gene uncharacterized protein Neighboring gene Syntaxin 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions. Bachmann A, et al. J Neurosci, 2010 Apr 28. PMID 20427642, Free PMC Article
    2. Genome-wide quantitative enhancer activity maps identified by STARR-seq. Arnold CD, et al. Science, 2013 Mar 1. PMID 23328393
    3. Specific SR protein-dependent splicing substrates identified through genomic SELEX. Kim S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655012, Free PMC Article
    4. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article
    5. Drosophila Varicose, a member of a new subgroup of basolateral MAGUKs, is required for septate junctions and tracheal morphogenesis. Wu VM, et al. Development, 2007 Mar. PMID 17267446, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in subsynaptic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    menage a trois
    Names
    CG30021-PA
    CG30021-PB
    CG30021-PC
    CG30021-PD
    metro-PA
    metro-PB
    metro-PC
    metro-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11226458..11232516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299380.1 → NP_001286309.1  menage a trois, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286309.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF49
      Conserved Domains (5) summary
      smart00569
      Location:75 → 127
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd11862
      Location:233 → 292
      SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
      smart00072
      Location:350 → 531
      GuKc; Guanylate kinase homologues
      cd00992
      Location:139 → 219
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:341 → 526
      Guanylate_kin; Guanylate kinase

    2. NM_001144171.2 → NP_001137643.1  menage a trois, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137643.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZF0
      Conserved Domains (5) summary
      smart00569
      Location:75 → 127
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd11862
      Location:233 → 292
      SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
      smart00072
      Location:389 → 570
      GuKc; Guanylate kinase homologues
      cd00992
      Location:139 → 219
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:380 → 565
      Guanylate_kin; Guanylate kinase

    3. NM_001144170.2 → NP_001137642.1  menage a trois, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137642.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T5S9, Q9V5U0
      Conserved Domains (5) summary
      smart00569
      Location:75 → 127
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd11862
      Location:243 → 302
      SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
      smart00072
      Location:360 → 541
      GuKc; Guanylate kinase homologues
      cd00992
      Location:139 → 229
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:351 → 536
      Guanylate_kin; Guanylate kinase

    4. NM_136798.3 → NP_610642.2  menage a trois, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610642.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8G0
      Conserved Domains (5) summary
      smart00569
      Location:75 → 127
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd11862
      Location:243 → 302
      SH3_MPP; Src Homology 3 domain of Membrane Protein, Palmitoylated (or MAGUK p55 subfamily member) proteins
      smart00072
      Location:399 → 580
      GuKc; Guanylate kinase homologues
      cd00992
      Location:139 → 229
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:390 → 575
      Guanylate_kin; Guanylate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF49 A0A0B4LF49
    A1Z8G0 A1Z8G0
    B7YZF0 B7YZF0
    Q8T5S9 Q8T5S9

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